Risk of smoking and metabolic syndrome for incidence of cardiovascular disease - Comparison of relative contribution in urban Japanese population: The suita study

Aya Higashiyama, Tomonori Okamura, Yuu Ono, Makoto Watanabe, Yoshihiro Kokubo, Akira Okayama

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Risk factor clustering, the so-called metabolic syndrome (MetS), is an important risk factor for cardiovascular disease (CVD). Smoking is also an important CVD risk factor with still a high prevalence. However, few previous studies have compared the risk for CVD or the population-attributable fraction (PAF) of smoking, MetS, and both. Methods and Results: The present study was an 11.9-year cohort study of 1,822 men and 2,089 women, aged 40-74 years, selected randomly from an urban general population in Japan. MetS was defined according to the National Cholesterol Education Program on Adult Treatment Panel III (NCEP-ATPIII) guideline modified by the Asian criteria for waist circumference. The prevalence of smoking was 49.5% in men and 11.1% in women, and that of MetS was 19.8% and 23.5%, respectively. In men, the multivariate-adjusted hazard ratio for CVD incidence, compared with non-smoking participants without MetS, was 2.07 (1.26-3.40) in those who smoked, 2.09 (1.08-4.04) in those with MetS, and 3.56 (1.89-6.72) in those with both. In men the PAF for CVD incidence was 21.8% because of smoking, 7.5% because of MetS, and 11.9% because of both. Conclusions: Although countermeasures for MetS are important, smoking should continue to be considered an important public health problem and antismoking campaigns should be promoted, especially for men, to prevent CVD.

Original languageEnglish
Pages (from-to)2258-2263
Number of pages6
JournalCirculation Journal
Volume73
Issue number12
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Urban Population
Cardiovascular Diseases
Smoking
Incidence
Waist Circumference
Population
Cluster Analysis
Japan
Cohort Studies
Public Health
Cholesterol
Guidelines
Education

Keywords

  • Cohort
  • Hazard ratio
  • Metabolic syndrome
  • Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Risk of smoking and metabolic syndrome for incidence of cardiovascular disease - Comparison of relative contribution in urban Japanese population : The suita study. / Higashiyama, Aya; Okamura, Tomonori; Ono, Yuu; Watanabe, Makoto; Kokubo, Yoshihiro; Okayama, Akira.

In: Circulation Journal, Vol. 73, No. 12, 2009, p. 2258-2263.

Research output: Contribution to journalArticle

@article{398f39f1ef884905a5d5086d9fe0f0ce,
title = "Risk of smoking and metabolic syndrome for incidence of cardiovascular disease - Comparison of relative contribution in urban Japanese population: The suita study",
abstract = "Background: Risk factor clustering, the so-called metabolic syndrome (MetS), is an important risk factor for cardiovascular disease (CVD). Smoking is also an important CVD risk factor with still a high prevalence. However, few previous studies have compared the risk for CVD or the population-attributable fraction (PAF) of smoking, MetS, and both. Methods and Results: The present study was an 11.9-year cohort study of 1,822 men and 2,089 women, aged 40-74 years, selected randomly from an urban general population in Japan. MetS was defined according to the National Cholesterol Education Program on Adult Treatment Panel III (NCEP-ATPIII) guideline modified by the Asian criteria for waist circumference. The prevalence of smoking was 49.5{\%} in men and 11.1{\%} in women, and that of MetS was 19.8{\%} and 23.5{\%}, respectively. In men, the multivariate-adjusted hazard ratio for CVD incidence, compared with non-smoking participants without MetS, was 2.07 (1.26-3.40) in those who smoked, 2.09 (1.08-4.04) in those with MetS, and 3.56 (1.89-6.72) in those with both. In men the PAF for CVD incidence was 21.8{\%} because of smoking, 7.5{\%} because of MetS, and 11.9{\%} because of both. Conclusions: Although countermeasures for MetS are important, smoking should continue to be considered an important public health problem and antismoking campaigns should be promoted, especially for men, to prevent CVD.",
keywords = "Cohort, Hazard ratio, Metabolic syndrome, Smoking",
author = "Aya Higashiyama and Tomonori Okamura and Yuu Ono and Makoto Watanabe and Yoshihiro Kokubo and Akira Okayama",
year = "2009",
doi = "10.1253/circj.CJ-09-0264",
language = "English",
volume = "73",
pages = "2258--2263",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "12",

}

TY - JOUR

T1 - Risk of smoking and metabolic syndrome for incidence of cardiovascular disease - Comparison of relative contribution in urban Japanese population

T2 - The suita study

AU - Higashiyama, Aya

AU - Okamura, Tomonori

AU - Ono, Yuu

AU - Watanabe, Makoto

AU - Kokubo, Yoshihiro

AU - Okayama, Akira

PY - 2009

Y1 - 2009

N2 - Background: Risk factor clustering, the so-called metabolic syndrome (MetS), is an important risk factor for cardiovascular disease (CVD). Smoking is also an important CVD risk factor with still a high prevalence. However, few previous studies have compared the risk for CVD or the population-attributable fraction (PAF) of smoking, MetS, and both. Methods and Results: The present study was an 11.9-year cohort study of 1,822 men and 2,089 women, aged 40-74 years, selected randomly from an urban general population in Japan. MetS was defined according to the National Cholesterol Education Program on Adult Treatment Panel III (NCEP-ATPIII) guideline modified by the Asian criteria for waist circumference. The prevalence of smoking was 49.5% in men and 11.1% in women, and that of MetS was 19.8% and 23.5%, respectively. In men, the multivariate-adjusted hazard ratio for CVD incidence, compared with non-smoking participants without MetS, was 2.07 (1.26-3.40) in those who smoked, 2.09 (1.08-4.04) in those with MetS, and 3.56 (1.89-6.72) in those with both. In men the PAF for CVD incidence was 21.8% because of smoking, 7.5% because of MetS, and 11.9% because of both. Conclusions: Although countermeasures for MetS are important, smoking should continue to be considered an important public health problem and antismoking campaigns should be promoted, especially for men, to prevent CVD.

AB - Background: Risk factor clustering, the so-called metabolic syndrome (MetS), is an important risk factor for cardiovascular disease (CVD). Smoking is also an important CVD risk factor with still a high prevalence. However, few previous studies have compared the risk for CVD or the population-attributable fraction (PAF) of smoking, MetS, and both. Methods and Results: The present study was an 11.9-year cohort study of 1,822 men and 2,089 women, aged 40-74 years, selected randomly from an urban general population in Japan. MetS was defined according to the National Cholesterol Education Program on Adult Treatment Panel III (NCEP-ATPIII) guideline modified by the Asian criteria for waist circumference. The prevalence of smoking was 49.5% in men and 11.1% in women, and that of MetS was 19.8% and 23.5%, respectively. In men, the multivariate-adjusted hazard ratio for CVD incidence, compared with non-smoking participants without MetS, was 2.07 (1.26-3.40) in those who smoked, 2.09 (1.08-4.04) in those with MetS, and 3.56 (1.89-6.72) in those with both. In men the PAF for CVD incidence was 21.8% because of smoking, 7.5% because of MetS, and 11.9% because of both. Conclusions: Although countermeasures for MetS are important, smoking should continue to be considered an important public health problem and antismoking campaigns should be promoted, especially for men, to prevent CVD.

KW - Cohort

KW - Hazard ratio

KW - Metabolic syndrome

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=73349084520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73349084520&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-09-0264

DO - 10.1253/circj.CJ-09-0264

M3 - Article

C2 - 19838005

AN - SCOPUS:73349084520

VL - 73

SP - 2258

EP - 2263

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 12

ER -