Abstract
Asian case-control studies have shown a strong relationship between the development of squamous cell carcinoma (SCC) of the esophagus and alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2*1/ *2), less-active alcohol dehydrogenase-1B (ADH1B*1/*1), high mean corpuscular volume (MCV), and self-reported facial flushing in response to alcohol. However, little is known about whether these risk factors prospectively influence cancer development in cancer-free alcoholics. Between 1993 and 2005,808 Japanese alcoholic men diagnosed as cancer-free by an initial endoscopic screening examination received follow-up examinations ranging from 1 to 148 months (median, 31 months) later, and SCC of the upper aerodigestive tract was diagnosed in 53 of them (esophagus in 33 and oropharyngolarynx in 30). Cox proportional hazards analysis showed that the age-adjusted relative hazard for SCC was 11.55 [95% confidence interval (95% CI), 5.73-23.3] in ALDH2*1/*2 heterozygotes compared with ALDH2*1/*1 homozygotes, 2.02 (95% CI, 1.02-4.02) in ADH1B*1/*1 homozygotes compared with ADH1B*1/*2 heterozygotes or *2/*2 homozygotes, 2.64 (95% CI, 1.49-4.67) in patients with flushing compared with those who had never experienced flushing, 2.91 (95% CI, 1.63-5.20) in those with an MCV ≥ 106 compared with those with an MCV < 106, 2.52 (95% CI, 1.22-5.22) in those who smoked >30 cigarettes per day compared with those who smoked 0 to 19 cigarettes per day, 7.26 (95% CI, 3.99-13.23) in those with esophageal dysplasia compared with those without distinct iodine-unstained lesions ≥5 mm, and 0.28 (95% CI, 0.09-0.85) in those with body mass index ≥ 23.2 (highest quartile) compared with those with body mass index < 19.0 (lowest quartile). These predictors are useful for selecting appropriately patients for careful follow-up examinations.
| Original language | English |
|---|---|
| Pages (from-to) | 2209-2215 |
| Number of pages | 7 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 15 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2006 Nov |
Fingerprint
ASJC Scopus subject areas
- Epidemiology
- Oncology
Cite this
Risk of squamous cell carcinoma of the upper aerodigestive tract in cancer-free alcoholic Japanese men : An endoscopic follow-up study. / Yokoyama, Akira; Omori, Tai; Yokoyama, Tetsuji; Sato, Yasuo; Mizukami, Takeshi; Matsushita, Sachio; Higuchi, Susumu; Maruyama, Katsuya; Ishii, Hiromasa; Hibi, Toshifumi.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 15, No. 11, 11.2006, p. 2209-2215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk of squamous cell carcinoma of the upper aerodigestive tract in cancer-free alcoholic Japanese men
T2 - An endoscopic follow-up study
AU - Yokoyama, Akira
AU - Omori, Tai
AU - Yokoyama, Tetsuji
AU - Sato, Yasuo
AU - Mizukami, Takeshi
AU - Matsushita, Sachio
AU - Higuchi, Susumu
AU - Maruyama, Katsuya
AU - Ishii, Hiromasa
AU - Hibi, Toshifumi
PY - 2006/11
Y1 - 2006/11
N2 - Asian case-control studies have shown a strong relationship between the development of squamous cell carcinoma (SCC) of the esophagus and alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2*1/ *2), less-active alcohol dehydrogenase-1B (ADH1B*1/*1), high mean corpuscular volume (MCV), and self-reported facial flushing in response to alcohol. However, little is known about whether these risk factors prospectively influence cancer development in cancer-free alcoholics. Between 1993 and 2005,808 Japanese alcoholic men diagnosed as cancer-free by an initial endoscopic screening examination received follow-up examinations ranging from 1 to 148 months (median, 31 months) later, and SCC of the upper aerodigestive tract was diagnosed in 53 of them (esophagus in 33 and oropharyngolarynx in 30). Cox proportional hazards analysis showed that the age-adjusted relative hazard for SCC was 11.55 [95% confidence interval (95% CI), 5.73-23.3] in ALDH2*1/*2 heterozygotes compared with ALDH2*1/*1 homozygotes, 2.02 (95% CI, 1.02-4.02) in ADH1B*1/*1 homozygotes compared with ADH1B*1/*2 heterozygotes or *2/*2 homozygotes, 2.64 (95% CI, 1.49-4.67) in patients with flushing compared with those who had never experienced flushing, 2.91 (95% CI, 1.63-5.20) in those with an MCV ≥ 106 compared with those with an MCV < 106, 2.52 (95% CI, 1.22-5.22) in those who smoked >30 cigarettes per day compared with those who smoked 0 to 19 cigarettes per day, 7.26 (95% CI, 3.99-13.23) in those with esophageal dysplasia compared with those without distinct iodine-unstained lesions ≥5 mm, and 0.28 (95% CI, 0.09-0.85) in those with body mass index ≥ 23.2 (highest quartile) compared with those with body mass index < 19.0 (lowest quartile). These predictors are useful for selecting appropriately patients for careful follow-up examinations.
AB - Asian case-control studies have shown a strong relationship between the development of squamous cell carcinoma (SCC) of the esophagus and alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2*1/ *2), less-active alcohol dehydrogenase-1B (ADH1B*1/*1), high mean corpuscular volume (MCV), and self-reported facial flushing in response to alcohol. However, little is known about whether these risk factors prospectively influence cancer development in cancer-free alcoholics. Between 1993 and 2005,808 Japanese alcoholic men diagnosed as cancer-free by an initial endoscopic screening examination received follow-up examinations ranging from 1 to 148 months (median, 31 months) later, and SCC of the upper aerodigestive tract was diagnosed in 53 of them (esophagus in 33 and oropharyngolarynx in 30). Cox proportional hazards analysis showed that the age-adjusted relative hazard for SCC was 11.55 [95% confidence interval (95% CI), 5.73-23.3] in ALDH2*1/*2 heterozygotes compared with ALDH2*1/*1 homozygotes, 2.02 (95% CI, 1.02-4.02) in ADH1B*1/*1 homozygotes compared with ADH1B*1/*2 heterozygotes or *2/*2 homozygotes, 2.64 (95% CI, 1.49-4.67) in patients with flushing compared with those who had never experienced flushing, 2.91 (95% CI, 1.63-5.20) in those with an MCV ≥ 106 compared with those with an MCV < 106, 2.52 (95% CI, 1.22-5.22) in those who smoked >30 cigarettes per day compared with those who smoked 0 to 19 cigarettes per day, 7.26 (95% CI, 3.99-13.23) in those with esophageal dysplasia compared with those without distinct iodine-unstained lesions ≥5 mm, and 0.28 (95% CI, 0.09-0.85) in those with body mass index ≥ 23.2 (highest quartile) compared with those with body mass index < 19.0 (lowest quartile). These predictors are useful for selecting appropriately patients for careful follow-up examinations.
UR - http://www.scopus.com/inward/record.url?scp=33845371974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845371974&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-06-0435
DO - 10.1158/1055-9965.EPI-06-0435
M3 - Article
C2 - 17119048
AN - SCOPUS:33845371974
VL - 15
SP - 2209
EP - 2215
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 11
ER -