Robust and adaptive control system for regulation of arterial gas pressures by using transcutaneous sensors

A. Sano, H. Ohmori, M. Yazawa, J. Xue, M. Kikuchi

Research output: Contribution to journalConference article


Robust and adaptive control schemes are investigated to regulate arterial oxygen pressure (PaCo2) and carbon dioxide pressure (PaCO2) independently at their desired levels by automatically adjusting two control inputs of the inspired oxygen concentration (FiO2) and the respiratory frequency (RF) in accordance with continuously monitored transcutaneous oxygen and carbon dioxide pressures (tcPO2 and tcPCO2). A linearized input-output model is given through the linearization at a steady-state level. The parameters and dead time in the linearized model are identified by using multiple models with a fixed dead time and adjustable parameters. In order to treat with individual differences and variations in the patient and the sensor dynamics and changes of the operating levels, the present control scheme consists of the adaptive control algorithm on a basis of the identified model and the robust controller with the Smith predictor to minimize the sensitivity to these variations. The effectiveness of the control scheme is investigated in animal experiments using mechanically ventilated dogs.

Original languageEnglish
Pages (from-to)1233-1238
Number of pages6
JournalIFAC Proceedings Series
Issue number8
Publication statusPublished - 1989 Dec 1
EventEighth IFAC/IFORS Symposium on Identification and System Parameter Estimation 1988. Part 1 - Beijing, China
Duration: 1988 Aug 271988 Aug 31


ASJC Scopus subject areas

  • Engineering(all)

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