TY - GEN
T1 - Robustness analysis of genetic circuits onstructed by bottom-up strategy
AU - Inoue, Masaki
AU - Arai, Takayuki
AU - Imura, Jun Ichi
AU - Kashima, Kenji
AU - Aihara, Kazuyuki
N1 - Funding Information:
⋆ This research is supported by the Aihara Innovative Mathematical Modelling Project, the Japan Society for the Promotion of Science (JSPS) through the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program), initiated by the Council for Science and Technology Policy (CSTP).
Publisher Copyright:
© IFAC.
PY - 2014
Y1 - 2014
N2 - We analyze the robustness of a system-level genetic circuit which is constructed by a bottom-up strategy. The latest trend in synthetic biology is to create large-scale and complex genetic circuits realizing desired programmable functions. An approach for the creation is bottom-up construction, that is, well-characterized small-scale circuits are coupled into large-scale system-level circuits involving desired programmable functions that can be predicted from the modules. However, in general, an intrinsic property in a circuit may be broken by internally connecting external circuits. We analyze a successful circuit created by a bottom-up construction strategy to identify the reason behind a successful synthesis. Utilizing the robustness analysis method based on the structured singular value, we can guarantee the validity of the bottom-up construction.
AB - We analyze the robustness of a system-level genetic circuit which is constructed by a bottom-up strategy. The latest trend in synthetic biology is to create large-scale and complex genetic circuits realizing desired programmable functions. An approach for the creation is bottom-up construction, that is, well-characterized small-scale circuits are coupled into large-scale system-level circuits involving desired programmable functions that can be predicted from the modules. However, in general, an intrinsic property in a circuit may be broken by internally connecting external circuits. We analyze a successful circuit created by a bottom-up construction strategy to identify the reason behind a successful synthesis. Utilizing the robustness analysis method based on the structured singular value, we can guarantee the validity of the bottom-up construction.
KW - Bi-stability
KW - Biocybernetics
KW - Robustness
KW - Structured singular value
KW - Uncertain dynamical systems
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U2 - 10.3182/20140824-6-za-1003.00962
DO - 10.3182/20140824-6-za-1003.00962
M3 - Conference contribution
AN - SCOPUS:84929728060
T3 - IFAC Proceedings Volumes (IFAC-PapersOnline)
SP - 1736
EP - 1741
BT - 19th IFAC World Congress IFAC 2014, Proceedings
A2 - Boje, Edward
A2 - Xia, Xiaohua
PB - IFAC Secretariat
T2 - 19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014
Y2 - 24 August 2014 through 29 August 2014
ER -