Robustness analysis of genetic circuits onstructed by bottom-up strategy

Masaki Inoue, Takayuki Arai, Jun Ichi Imura, Kenji Kashima, Kazuyuki Aihara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We analyze the robustness of a system-level genetic circuit which is constructed by a bottom-up strategy. The latest trend in synthetic biology is to create large-scale and complex genetic circuits realizing desired programmable functions. An approach for the creation is bottom-up construction, that is, well-characterized small-scale circuits are coupled into large-scale system-level circuits involving desired programmable functions that can be predicted from the modules. However, in general, an intrinsic property in a circuit may be broken by internally connecting external circuits. We analyze a successful circuit created by a bottom-up construction strategy to identify the reason behind a successful synthesis. Utilizing the robustness analysis method based on the structured singular value, we can guarantee the validity of the bottom-up construction.

Original languageEnglish
Title of host publication19th IFAC World Congress IFAC 2014, Proceedings
EditorsXiaohua Xia, Edward Boje
PublisherIFAC Secretariat
Pages1736-1741
Number of pages6
ISBN (Electronic)9783902823625
Publication statusPublished - 2014 Jan 1
Externally publishedYes
Event19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014 - Cape Town, South Africa
Duration: 2014 Aug 242014 Aug 29

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
Volume19
ISSN (Print)1474-6670

Other

Other19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014
CountrySouth Africa
CityCape Town
Period14/8/2414/8/29

Keywords

  • Bi-stability
  • Biocybernetics
  • Robustness
  • Structured singular value
  • Uncertain dynamical systems

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Inoue, M., Arai, T., Imura, J. I., Kashima, K., & Aihara, K. (2014). Robustness analysis of genetic circuits onstructed by bottom-up strategy. In X. Xia, & E. Boje (Eds.), 19th IFAC World Congress IFAC 2014, Proceedings (pp. 1736-1741). (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 19). IFAC Secretariat.