@inproceedings{3d18d99fd6af4db6b25e9b5da004e088,
title = "Robustness analysis of genetic circuits onstructed by bottom-up strategy",
abstract = "We analyze the robustness of a system-level genetic circuit which is constructed by a bottom-up strategy. The latest trend in synthetic biology is to create large-scale and complex genetic circuits realizing desired programmable functions. An approach for the creation is bottom-up construction, that is, well-characterized small-scale circuits are coupled into large-scale system-level circuits involving desired programmable functions that can be predicted from the modules. However, in general, an intrinsic property in a circuit may be broken by internally connecting external circuits. We analyze a successful circuit created by a bottom-up construction strategy to identify the reason behind a successful synthesis. Utilizing the robustness analysis method based on the structured singular value, we can guarantee the validity of the bottom-up construction.",
keywords = "Bi-stability, Biocybernetics, Robustness, Structured singular value, Uncertain dynamical systems",
author = "Masaki Inoue and Takayuki Arai and Imura, {Jun Ichi} and Kenji Kashima and Kazuyuki Aihara",
year = "2014",
month = jan,
day = "1",
language = "English",
series = "IFAC Proceedings Volumes (IFAC-PapersOnline)",
publisher = "IFAC Secretariat",
pages = "1736--1741",
editor = "Xiaohua Xia and Edward Boje",
booktitle = "19th IFAC World Congress IFAC 2014, Proceedings",
note = "19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014 ; Conference date: 24-08-2014 Through 29-08-2014",
}