Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats

Yae Kanai, Shingo Hori, Tsuyoshi Tanaka, Megumi Yasuoka, Kazuo Watanabe, Naoki Aikawa, Yasuhiro Hosoda

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Objective: The aim was to clarify the role of serotonin (5-hydroxytryptamine, 5-HT) in monocrotaline induced pulmonary hypertension. Methods: Plasma 5-HT levels, pulmonary capillary platelet count, and vascular responsiveness to 5-HT were evaluated in the model. The effects of the selective 5-HT2 receptor antagonist, DV- 7028, on the development of pulmonary hypertension were also investigated. Results: Plasma 5-HT was raised 12 h to 3 d after monocrotaline administration (60 mg·kg-1), coinciding with accumulation of platelets in the pulmonary circulation. Isolated pulmonary arteries showed hyperreactivity to 5-HT at 14 and 21 d after monocrotaline. Administration of DV-7028 (20 mg·kg-1·d-1) attenuated the increase in pulmonary arterial pressure, right ventricular hypertrophy, and medial thickening of the pulmonary arteries. Conclusions: The present study suggests that 5-HT released from platelets contributes to the initiation and progression of monocrotaline induced pulmonary hypertension.Cardiovascular Research 1993;27:1619-1623.

Original languageEnglish
Pages (from-to)1619-1623
Number of pages5
JournalCardiovascular Research
Issue number9
Publication statusPublished - 1993 Jan 1



  • DV-7028
  • Monocrotaline
  • Pulmonary hypertension
  • Serotonin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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