Role of ADF/TRX and Its Inhibitor on the Release of Major Basic Protein from Human Eosinophils

H. Koyanagi, N. Wakasugi, K. Yoshimatsu, Y. Takashima, J. J. Yodoi, M. Momoi, T. Suda, T. Kasahara, Y. Yamaguchi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), originally defined as an IL-2 receptor α-chain/p55 inducer, has many cytokine-like activities. We reported that the release of major basic protein (MBP) from mature eosinophils stimulated with cytochalasin B and C5a were augmented after preincubation with recombinant ADF/TRX. The addition of a TRX specific inhibitor, BE40644, suppressed the augmentation of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils.

Original languageEnglish
Pages (from-to)1140-1147
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume213
Issue number3
DOIs
Publication statusPublished - 1995 Aug 24

Fingerprint

Thioredoxins
Eosinophils
Eosinophil Major Basic Protein
Cytochalasin B
Interleukin-2 Receptors
Proteins
Cytokines
human PRG2 protein
BE 40644

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biophysics
  • Biochemistry

Cite this

Koyanagi, H., Wakasugi, N., Yoshimatsu, K., Takashima, Y., Yodoi, J. J., Momoi, M., ... Yamaguchi, Y. (1995). Role of ADF/TRX and Its Inhibitor on the Release of Major Basic Protein from Human Eosinophils. Biochemical and Biophysical Research Communications, 213(3), 1140-1147. https://doi.org/10.1006/bbrc.1995.2245

Role of ADF/TRX and Its Inhibitor on the Release of Major Basic Protein from Human Eosinophils. / Koyanagi, H.; Wakasugi, N.; Yoshimatsu, K.; Takashima, Y.; Yodoi, J. J.; Momoi, M.; Suda, T.; Kasahara, T.; Yamaguchi, Y.

In: Biochemical and Biophysical Research Communications, Vol. 213, No. 3, 24.08.1995, p. 1140-1147.

Research output: Contribution to journalArticle

Koyanagi, H, Wakasugi, N, Yoshimatsu, K, Takashima, Y, Yodoi, JJ, Momoi, M, Suda, T, Kasahara, T & Yamaguchi, Y 1995, 'Role of ADF/TRX and Its Inhibitor on the Release of Major Basic Protein from Human Eosinophils', Biochemical and Biophysical Research Communications, vol. 213, no. 3, pp. 1140-1147. https://doi.org/10.1006/bbrc.1995.2245
Koyanagi, H. ; Wakasugi, N. ; Yoshimatsu, K. ; Takashima, Y. ; Yodoi, J. J. ; Momoi, M. ; Suda, T. ; Kasahara, T. ; Yamaguchi, Y. / Role of ADF/TRX and Its Inhibitor on the Release of Major Basic Protein from Human Eosinophils. In: Biochemical and Biophysical Research Communications. 1995 ; Vol. 213, No. 3. pp. 1140-1147.
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