Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils

Hideki Koyanagi, Naomi Wakasugi, Kentaro Yoshimatsu, Yuichiro Takashima, Junji J. Yodoi, Mariko Momoi, Toshio Suda, Tadashi Kasahara, Yuji Yamaguchi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), originally defined as an IL-2 receptor α-chain/p55 inducer, has many cytokine-like activities. We reported that the release of major basic protein (MBP) from mature eosinophils stimulated with cytochalasin B and C5a were augmented after preincubation with recombinant ADF/TRX. The addition of a TRX specific inhibitor, BE40644, suppressed the augmentation of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils.

Original languageEnglish
Pages (from-to)1140-1147
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume213
Issue number3
DOIs
Publication statusPublished - 1995 Jan 1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Koyanagi, H., Wakasugi, N., Yoshimatsu, K., Takashima, Y., Yodoi, J. J., Momoi, M., Suda, T., Kasahara, T., & Yamaguchi, Y. (1995). Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils. Biochemical and Biophysical Research Communications, 213(3), 1140-1147. https://doi.org/10.1006/bbrc.1995.2245