TY - JOUR
T1 - Role of adrenomedullin and its receptor system in renal pathophysiology
AU - Mukoyama, Masashi
AU - Sugawara, Akira
AU - Nagae, Tetsuya
AU - Mori, Kiyoshi
AU - Murabe, Hiroyuki
AU - Itoh, Hiroshi
AU - Tanaka, Issei
AU - Nakao, Kazuwa
N1 - Funding Information:
We gratefully thank members of our laboratory for helpful discussions during the course of these studies. We acknowledge Ms. J. Nakamura and Ms. A. Wada for technical assistance, and Ms. S. Doi and Ms. A. Sonoda for secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Education, Science, Sports and Culture, the Japanese Ministry of Health and Welfare, “Research for the Future (RFTF)” of Japan Society for the Promotion of Science, the Smoking Research Foundation, and the Salt Science Research Foundation.
PY - 2001
Y1 - 2001
N2 - Adrenomedullin (AM), a potent vasorelaxing, natriuretic and cell growth-modulating peptide, is thought to act as an autocrine/paracrine regulator in renal glomeruli and tubules. AM receptors comprise the calcitonin receptor-like receptor (CRLR) and a family of receptor-activity-modifying proteins (RAMPs 1-3); however, the pathophysiological role of AM and its receptor system in the kidney remains to be clarified. We examined the regulation of their expression in a rat model of renal injury and found that RAMP1, RAMP2 and CRLR expressions were markedly upregulated upon induction of fibrosis during obstructive nephropathy. Since AM exerts potent antiproliferative effects in various cell types, upregulation of the AM receptor system may play important roles in modulating the progression of renal diseases.
AB - Adrenomedullin (AM), a potent vasorelaxing, natriuretic and cell growth-modulating peptide, is thought to act as an autocrine/paracrine regulator in renal glomeruli and tubules. AM receptors comprise the calcitonin receptor-like receptor (CRLR) and a family of receptor-activity-modifying proteins (RAMPs 1-3); however, the pathophysiological role of AM and its receptor system in the kidney remains to be clarified. We examined the regulation of their expression in a rat model of renal injury and found that RAMP1, RAMP2 and CRLR expressions were markedly upregulated upon induction of fibrosis during obstructive nephropathy. Since AM exerts potent antiproliferative effects in various cell types, upregulation of the AM receptor system may play important roles in modulating the progression of renal diseases.
KW - Adrenomedullin
KW - Adrenomedullin receptor
KW - Calcitonin receptor-like receptor (CRLR)
KW - Mesangium
KW - Obstructive nephropathy
KW - Receptor-activity-modifying proteins (RAMPs)
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U2 - 10.1016/S0196-9781(01)00525-3
DO - 10.1016/S0196-9781(01)00525-3
M3 - Article
C2 - 11754983
AN - SCOPUS:0035685271
SN - 0196-9781
VL - 22
SP - 1925
EP - 1931
JO - Peptides
JF - Peptides
IS - 11
ER -