Role of endogenous atrial natriuretic peptide in congestive heart failure

M. Awazu, T. Imada, V. Kon, T. Inagami, I. Ichikawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Effects of purified rabbit anti-rat 25-amino acid atrial natriuretic peptide (ANP) immunoglobulin G (IgG) on renal sodium excretion and glomerular filtration rate were studied in a rat model of congestive heart failure (CHF) having high circulating ANP levels. Bolus injection of anti-ANP into anesthetized rats with surgically induced myocardial infarction (MI) significantly and markedly depressed both absolute and fractional urinary excretion of sodium without affecting mean arterial pressure or glomerular filtration rate. By contrast, anti-ANP failed to affect these renal functions in normal or acutely water-deprived rats. Nonimmune IgG did not affect renal function in MI rats. These results indicate that high circulating ANP plays an important role in sodium homeostasis of congestive heart failure: by promoting sodium excretion, ANP opposes the tendency of sodium retention characteristic of CHF.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume257
Issue number3
Publication statusPublished - 1989
Externally publishedYes

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Atrial Natriuretic Factor
Heart Failure
Sodium
Glomerular Filtration Rate
Immunoglobulin G
Myocardial Infarction
Kidney
Arterial Pressure
Homeostasis
Rabbits
Amino Acids
Injections
Water

ASJC Scopus subject areas

  • Physiology

Cite this

Role of endogenous atrial natriuretic peptide in congestive heart failure. / Awazu, M.; Imada, T.; Kon, V.; Inagami, T.; Ichikawa, I.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 257, No. 3, 1989.

Research output: Contribution to journalArticle

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