Abstract
Background and Aim: Plasma high density lipoprotein cholesterol (HDL-C) levels are determined by a variety of environmental and genetic factors. The cholesteryl ester transfer protein (CETP) and apolipoprotein A-I (Apo A-I) are considered to be associated with HDL-C metabolism. The aim of this study was to investigate the relationship between the CETP gene Taq I B and Apo A-I gene Msp I polymorphisms and plasma lipid levels taking into account environmental factors, and to determine the combined effects of these polymorphisms on HDL-C levels in Japanese women. Methods and Results: The study involved 270 Japanese women aged 30-69 years. We found a significant association between the CETP genotypes and HDL-C levels (p=0.0020), which were also associated with the Apo A-I gene (M1) polymorphism. Stepwise multiple regression analysis revealed that both the CETP Taq I B and Apo A-I gene (M1) genotypes were independent predictive variables. The strength of the association between the Apo A-I (M1) subgroup and HDL-C levels was reduced in the subjects with a high Body Mass Index (BMI). The combination of genotypes provided more detailed information about HDL-C levels. The "high risk" combination of the M1+ (M1+/+) and B1B1 genotypes was associated with the lowest HDL-C level (1.52±0.36 mmol/L), and the "low risk" combination of the M1- (M1+/-or M1-/-) and B2B2 genotypes was associated with the highest HDL-C levels (2.06±0.34 mmol/L). Conclusions: Our results suggest that the combination of the two polymorphisms influences HDL-C levels in women, and that the association between genetic factors and HDL-C levels is altered by environmental factors. They may also help to detect individuals with low HDL-C levels at high risk for coronary artery syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 6-14 |
| Number of pages | 9 |
| Journal | Nutrition, Metabolism and Cardiovascular Diseases |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2004 Feb |
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Keywords
- Apolipoprotein A-I
- Body mass index
- Cholesteryl ester transfer protein (CETP)
- Gene
- High density lipoprotein cholesterol (HDL-C)
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Medicine (miscellaneous)
- Food Science
- Endocrinology, Diabetes and Metabolism
Cite this
Role of genetic factors (CETP gene Taq I B polymorphism and Apo A-I gene Msp I polymorphism) in serum HDL-C levels in women. / Motohashi, Y.; Maruyama, T.; Murata, Mitsuru; Nakano, S.; Maruyama, C.; Kyotani, S.; Tsushima, M.; Saruta, T.
In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 14, No. 1, 02.2004, p. 6-14.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of genetic factors (CETP gene Taq I B polymorphism and Apo A-I gene Msp I polymorphism) in serum HDL-C levels in women
AU - Motohashi, Y.
AU - Maruyama, T.
AU - Murata, Mitsuru
AU - Nakano, S.
AU - Maruyama, C.
AU - Kyotani, S.
AU - Tsushima, M.
AU - Saruta, T.
PY - 2004/2
Y1 - 2004/2
N2 - Background and Aim: Plasma high density lipoprotein cholesterol (HDL-C) levels are determined by a variety of environmental and genetic factors. The cholesteryl ester transfer protein (CETP) and apolipoprotein A-I (Apo A-I) are considered to be associated with HDL-C metabolism. The aim of this study was to investigate the relationship between the CETP gene Taq I B and Apo A-I gene Msp I polymorphisms and plasma lipid levels taking into account environmental factors, and to determine the combined effects of these polymorphisms on HDL-C levels in Japanese women. Methods and Results: The study involved 270 Japanese women aged 30-69 years. We found a significant association between the CETP genotypes and HDL-C levels (p=0.0020), which were also associated with the Apo A-I gene (M1) polymorphism. Stepwise multiple regression analysis revealed that both the CETP Taq I B and Apo A-I gene (M1) genotypes were independent predictive variables. The strength of the association between the Apo A-I (M1) subgroup and HDL-C levels was reduced in the subjects with a high Body Mass Index (BMI). The combination of genotypes provided more detailed information about HDL-C levels. The "high risk" combination of the M1+ (M1+/+) and B1B1 genotypes was associated with the lowest HDL-C level (1.52±0.36 mmol/L), and the "low risk" combination of the M1- (M1+/-or M1-/-) and B2B2 genotypes was associated with the highest HDL-C levels (2.06±0.34 mmol/L). Conclusions: Our results suggest that the combination of the two polymorphisms influences HDL-C levels in women, and that the association between genetic factors and HDL-C levels is altered by environmental factors. They may also help to detect individuals with low HDL-C levels at high risk for coronary artery syndrome.
AB - Background and Aim: Plasma high density lipoprotein cholesterol (HDL-C) levels are determined by a variety of environmental and genetic factors. The cholesteryl ester transfer protein (CETP) and apolipoprotein A-I (Apo A-I) are considered to be associated with HDL-C metabolism. The aim of this study was to investigate the relationship between the CETP gene Taq I B and Apo A-I gene Msp I polymorphisms and plasma lipid levels taking into account environmental factors, and to determine the combined effects of these polymorphisms on HDL-C levels in Japanese women. Methods and Results: The study involved 270 Japanese women aged 30-69 years. We found a significant association between the CETP genotypes and HDL-C levels (p=0.0020), which were also associated with the Apo A-I gene (M1) polymorphism. Stepwise multiple regression analysis revealed that both the CETP Taq I B and Apo A-I gene (M1) genotypes were independent predictive variables. The strength of the association between the Apo A-I (M1) subgroup and HDL-C levels was reduced in the subjects with a high Body Mass Index (BMI). The combination of genotypes provided more detailed information about HDL-C levels. The "high risk" combination of the M1+ (M1+/+) and B1B1 genotypes was associated with the lowest HDL-C level (1.52±0.36 mmol/L), and the "low risk" combination of the M1- (M1+/-or M1-/-) and B2B2 genotypes was associated with the highest HDL-C levels (2.06±0.34 mmol/L). Conclusions: Our results suggest that the combination of the two polymorphisms influences HDL-C levels in women, and that the association between genetic factors and HDL-C levels is altered by environmental factors. They may also help to detect individuals with low HDL-C levels at high risk for coronary artery syndrome.
KW - Apolipoprotein A-I
KW - Body mass index
KW - Cholesteryl ester transfer protein (CETP)
KW - Gene
KW - High density lipoprotein cholesterol (HDL-C)
UR - http://www.scopus.com/inward/record.url?scp=2342652306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2342652306&partnerID=8YFLogxK
U2 - 10.1016/S0939-4753(04)80041-3
DO - 10.1016/S0939-4753(04)80041-3
M3 - Article
VL - 14
SP - 6
EP - 14
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 1
ER -