Role of GluR1 in activity-dependent motor system development

Lei Zhang, Joachim Schessl, Markus Werner, Carsten Bonnemann, Guoxiang Xiong, Jelena Mojsilovic-Petrovic, Weiguo Zhou, Akiva Cohen, Peter Seeburg, Hidemi Misawa, Aditi Jayaram, Kirkwood Personius, Michael Hollmann, Rolf Sprengel, Robert Kalb

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Activity-dependent specification of neuronal architecture during early postnatal life is essential for refining the precision of communication between neurons. In the spinal cord under normal circumstances, the AMPA receptor subunit GluR1 is expressed at high levels by motor neurons and surrounding interneurons during this critical developmental period, although the role it plays in circuit formation and locomotor behavior is unknown. Here, we show that GluR1 promotes dendrite growth in a non-cell-autonomous manner in vitro and in vivo. The mal-development of motor neuron dendrites is associated with changes in the pattern of interneuronal connectivity within the segmental spinal cord and defects in strength and endurance. Transgenic expression of GluR1 in adult motor neurons leads to dendrite remodeling and supernormal locomotor function. GluR1 expression by neurons within the segmental spinal cord plays an essential role in formation of the neural network that underlies normal motor behavior.

Original languageEnglish
Pages (from-to)9953-9968
Number of pages16
JournalJournal of Neuroscience
Volume28
Issue number40
DOIs
Publication statusPublished - 2008 Oct 1

Fingerprint

Motor Neurons
Dendrites
Spinal Cord
Motor Activity
Neurons
Interneurons
Communication
Growth

Keywords

  • Glutamate receptors
  • Motor behavior
  • Motor neurons
  • Network activity
  • Spinal cord
  • Synaptic activity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Zhang, L., Schessl, J., Werner, M., Bonnemann, C., Xiong, G., Mojsilovic-Petrovic, J., ... Kalb, R. (2008). Role of GluR1 in activity-dependent motor system development. Journal of Neuroscience, 28(40), 9953-9968. https://doi.org/10.1523/JNEUROSCI.0880-08.2008

Role of GluR1 in activity-dependent motor system development. / Zhang, Lei; Schessl, Joachim; Werner, Markus; Bonnemann, Carsten; Xiong, Guoxiang; Mojsilovic-Petrovic, Jelena; Zhou, Weiguo; Cohen, Akiva; Seeburg, Peter; Misawa, Hidemi; Jayaram, Aditi; Personius, Kirkwood; Hollmann, Michael; Sprengel, Rolf; Kalb, Robert.

In: Journal of Neuroscience, Vol. 28, No. 40, 01.10.2008, p. 9953-9968.

Research output: Contribution to journalArticle

Zhang, L, Schessl, J, Werner, M, Bonnemann, C, Xiong, G, Mojsilovic-Petrovic, J, Zhou, W, Cohen, A, Seeburg, P, Misawa, H, Jayaram, A, Personius, K, Hollmann, M, Sprengel, R & Kalb, R 2008, 'Role of GluR1 in activity-dependent motor system development', Journal of Neuroscience, vol. 28, no. 40, pp. 9953-9968. https://doi.org/10.1523/JNEUROSCI.0880-08.2008
Zhang L, Schessl J, Werner M, Bonnemann C, Xiong G, Mojsilovic-Petrovic J et al. Role of GluR1 in activity-dependent motor system development. Journal of Neuroscience. 2008 Oct 1;28(40):9953-9968. https://doi.org/10.1523/JNEUROSCI.0880-08.2008
Zhang, Lei ; Schessl, Joachim ; Werner, Markus ; Bonnemann, Carsten ; Xiong, Guoxiang ; Mojsilovic-Petrovic, Jelena ; Zhou, Weiguo ; Cohen, Akiva ; Seeburg, Peter ; Misawa, Hidemi ; Jayaram, Aditi ; Personius, Kirkwood ; Hollmann, Michael ; Sprengel, Rolf ; Kalb, Robert. / Role of GluR1 in activity-dependent motor system development. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 40. pp. 9953-9968.
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