Role of iPSC-Producing Factors in Pre-Implantation Embryos

Tomokazu Amano, Minoru Ko

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Although the induced pluripotent stem cell (iPSC) procedure has clearly become the method of choice because of its convenience and for ethical considerations, when generating pluripotent stem cells from somatic cells, it is still important to consider the number of advantageous features of the somatic cell nuclear transfer procedure. For example, it will be interesting to discover whether iPSC factors, which were originally identified as genes expressed specifically in embryonic stem cells, can account for all of the unknown reprogramming factors present in pre-implantation embryos. With this point in mind, in this chapter we will review each reprogramming factor that has been reported in mouse and human iPSC studies from the perspective of its expression pattern in pre-implantation embryos. We will also examine some of the candidate genes that are expressed in pre-implantation embryos but do not form part of the common iPSC factors due to their lack of or low expression in embryonic stem cells, because such factors may help to efficiently produce high-quality iPSCs.

Original languageEnglish
Title of host publicationPrinciples of Cloning: Second Edition
PublisherElsevier Inc.
Pages473-484
Number of pages12
ISBN (Print)9780123865410
DOIs
Publication statusPublished - 2013 Oct

Fingerprint

Induced Pluripotent Stem Cells
Stem Cell Factor
Stem cells
Embryonic Stem Cells
Pluripotent Stem Cells
Genes

Keywords

  • Cloning
  • IPSC-producing factors
  • Nuclear transfer
  • Pluripotent stem cells
  • Pre-implantation embryo
  • Reprogramming

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Amano, T., & Ko, M. (2013). Role of iPSC-Producing Factors in Pre-Implantation Embryos. In Principles of Cloning: Second Edition (pp. 473-484). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386541-0.00038-2

Role of iPSC-Producing Factors in Pre-Implantation Embryos. / Amano, Tomokazu; Ko, Minoru.

Principles of Cloning: Second Edition. Elsevier Inc., 2013. p. 473-484.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amano, T & Ko, M 2013, Role of iPSC-Producing Factors in Pre-Implantation Embryos. in Principles of Cloning: Second Edition. Elsevier Inc., pp. 473-484. https://doi.org/10.1016/B978-0-12-386541-0.00038-2
Amano T, Ko M. Role of iPSC-Producing Factors in Pre-Implantation Embryos. In Principles of Cloning: Second Edition. Elsevier Inc. 2013. p. 473-484 https://doi.org/10.1016/B978-0-12-386541-0.00038-2
Amano, Tomokazu ; Ko, Minoru. / Role of iPSC-Producing Factors in Pre-Implantation Embryos. Principles of Cloning: Second Edition. Elsevier Inc., 2013. pp. 473-484
@inbook{6671609d537c4562bff77324f0dcd4d1,
title = "Role of iPSC-Producing Factors in Pre-Implantation Embryos",
abstract = "Although the induced pluripotent stem cell (iPSC) procedure has clearly become the method of choice because of its convenience and for ethical considerations, when generating pluripotent stem cells from somatic cells, it is still important to consider the number of advantageous features of the somatic cell nuclear transfer procedure. For example, it will be interesting to discover whether iPSC factors, which were originally identified as genes expressed specifically in embryonic stem cells, can account for all of the unknown reprogramming factors present in pre-implantation embryos. With this point in mind, in this chapter we will review each reprogramming factor that has been reported in mouse and human iPSC studies from the perspective of its expression pattern in pre-implantation embryos. We will also examine some of the candidate genes that are expressed in pre-implantation embryos but do not form part of the common iPSC factors due to their lack of or low expression in embryonic stem cells, because such factors may help to efficiently produce high-quality iPSCs.",
keywords = "Cloning, IPSC-producing factors, Nuclear transfer, Pluripotent stem cells, Pre-implantation embryo, Reprogramming",
author = "Tomokazu Amano and Minoru Ko",
year = "2013",
month = "10",
doi = "10.1016/B978-0-12-386541-0.00038-2",
language = "English",
isbn = "9780123865410",
pages = "473--484",
booktitle = "Principles of Cloning: Second Edition",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Role of iPSC-Producing Factors in Pre-Implantation Embryos

AU - Amano, Tomokazu

AU - Ko, Minoru

PY - 2013/10

Y1 - 2013/10

N2 - Although the induced pluripotent stem cell (iPSC) procedure has clearly become the method of choice because of its convenience and for ethical considerations, when generating pluripotent stem cells from somatic cells, it is still important to consider the number of advantageous features of the somatic cell nuclear transfer procedure. For example, it will be interesting to discover whether iPSC factors, which were originally identified as genes expressed specifically in embryonic stem cells, can account for all of the unknown reprogramming factors present in pre-implantation embryos. With this point in mind, in this chapter we will review each reprogramming factor that has been reported in mouse and human iPSC studies from the perspective of its expression pattern in pre-implantation embryos. We will also examine some of the candidate genes that are expressed in pre-implantation embryos but do not form part of the common iPSC factors due to their lack of or low expression in embryonic stem cells, because such factors may help to efficiently produce high-quality iPSCs.

AB - Although the induced pluripotent stem cell (iPSC) procedure has clearly become the method of choice because of its convenience and for ethical considerations, when generating pluripotent stem cells from somatic cells, it is still important to consider the number of advantageous features of the somatic cell nuclear transfer procedure. For example, it will be interesting to discover whether iPSC factors, which were originally identified as genes expressed specifically in embryonic stem cells, can account for all of the unknown reprogramming factors present in pre-implantation embryos. With this point in mind, in this chapter we will review each reprogramming factor that has been reported in mouse and human iPSC studies from the perspective of its expression pattern in pre-implantation embryos. We will also examine some of the candidate genes that are expressed in pre-implantation embryos but do not form part of the common iPSC factors due to their lack of or low expression in embryonic stem cells, because such factors may help to efficiently produce high-quality iPSCs.

KW - Cloning

KW - IPSC-producing factors

KW - Nuclear transfer

KW - Pluripotent stem cells

KW - Pre-implantation embryo

KW - Reprogramming

UR - http://www.scopus.com/inward/record.url?scp=84903221810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903221810&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-386541-0.00038-2

DO - 10.1016/B978-0-12-386541-0.00038-2

M3 - Chapter

AN - SCOPUS:84903221810

SN - 9780123865410

SP - 473

EP - 484

BT - Principles of Cloning: Second Edition

PB - Elsevier Inc.

ER -