Role of mitochondria in alcoholic liver injury

Masayuki Adachi, Hiromasa Ishii

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Oxidative stress and oxygen-derived free radicals are well known to play an important role in the pathogenesis of ethanol-associated liver injury. Active oxidants produced during ethanol metabolism induce mitochondrial membrane depolarization and permeability changes in cultured hepatocytes. These mitochondrial alterations (loss of ΔΨm and mitochondrial permeability transition [MPT]) are now recognized as a key step in apoptosis. In recent studies, including ours, the MPT has been identified as a key step for the induction of mitochondrial cytochrome c release and caspase activation by ethanol. In addition, chronic and/or acute ethanol modulates intracellular, especially mitochondrial, antioxidant levels, leading to the increased susceptibility to alcoholic liver injury induced by several apoptotic stimuli. In this review, we address the mechanism of mitochondrial alterations and liver injury induced by ethanol.

Original languageEnglish
Pages (from-to)487-491
Number of pages5
JournalFree Radical Biology and Medicine
Volume32
Issue number6
DOIs
Publication statusPublished - 2002 Mar 15

Fingerprint

Mitochondria
Liver
Ethanol
Wounds and Injuries
Permeability
Oxidative stress
Depolarization
Mitochondrial Membranes
Caspases
Cytochromes c
Oxidants
Metabolism
Free Radicals
Hepatocytes
Oxidative Stress
Antioxidants
Chemical activation
Apoptosis
Oxygen
Membranes

Keywords

  • Apoptosis
  • Cytochrome c
  • Free radicals
  • Glutathione
  • Mitochondria
  • Mitochondrial permeability transition
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Clinical Biochemistry

Cite this

Role of mitochondria in alcoholic liver injury. / Adachi, Masayuki; Ishii, Hiromasa.

In: Free Radical Biology and Medicine, Vol. 32, No. 6, 15.03.2002, p. 487-491.

Research output: Contribution to journalArticle

Adachi, Masayuki ; Ishii, Hiromasa. / Role of mitochondria in alcoholic liver injury. In: Free Radical Biology and Medicine. 2002 ; Vol. 32, No. 6. pp. 487-491.
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