TY - GEN
T1 - Role of Na+-Ca2+ exchange in neonatal and adult ventricular cells
T2 - 39th Computing in Cardiology Conference, CinC 2012
AU - Sano, Hitomi I.
AU - Naito, Yasuhiro
AU - Tomita, Masaru
PY - 2012/12/1
Y1 - 2012/12/1
N2 - The Na+-Ca2+ exchange assumes considerable importance in neonatal cells with a morphologically sparse sarcoplasmic reticulum. Our simulation shows that the neonatal ventricular cell consumed larger amount of ATP than the adult ventricular cell, owing to a long relaxation time. The amount of ATP consumed per beat was reduced to the amount equivalent to the adult ventricular cells, thus increasing the relative current density of Na +-Ca2+ exchange by 4-fold, which is consistent with the observed current density in the neonatal rabbit ventricular cells.
AB - The Na+-Ca2+ exchange assumes considerable importance in neonatal cells with a morphologically sparse sarcoplasmic reticulum. Our simulation shows that the neonatal ventricular cell consumed larger amount of ATP than the adult ventricular cell, owing to a long relaxation time. The amount of ATP consumed per beat was reduced to the amount equivalent to the adult ventricular cells, thus increasing the relative current density of Na +-Ca2+ exchange by 4-fold, which is consistent with the observed current density in the neonatal rabbit ventricular cells.
UR - http://www.scopus.com/inward/record.url?scp=84875642070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875642070&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84875642070
SN - 9781467320740
T3 - Computing in Cardiology
SP - 877
EP - 880
BT - Computing in Cardiology 2012, CinC 2012
Y2 - 9 September 2012 through 12 September 2012
ER -