Role of Na+-Ca2+ exchange in neonatal and adult ventricular cells: A simulation study

Hitomi I. Sano, Yasuhiro Naito, Masaru Tomita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Na+-Ca2+ exchange assumes considerable importance in neonatal cells with a morphologically sparse sarcoplasmic reticulum. Our simulation shows that the neonatal ventricular cell consumed larger amount of ATP than the adult ventricular cell, owing to a long relaxation time. The amount of ATP consumed per beat was reduced to the amount equivalent to the adult ventricular cells, thus increasing the relative current density of Na +-Ca2+ exchange by 4-fold, which is consistent with the observed current density in the neonatal rabbit ventricular cells.

Original languageEnglish
Title of host publicationComputing in Cardiology 2012, CinC 2012
Pages877-880
Number of pages4
Publication statusPublished - 2012 Dec 1
Event39th Computing in Cardiology Conference, CinC 2012 - Krakow, Poland
Duration: 2012 Sep 92012 Sep 12

Publication series

NameComputing in Cardiology
Volume39
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Other

Other39th Computing in Cardiology Conference, CinC 2012
CountryPoland
CityKrakow
Period12/9/912/9/12

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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