Role of nitric oxide in the control of blood pressure in young and adult spontaneously hypertensive rats

Y. Akiba, N. Yamaguchi, H. Amano, T. Fujii, Kazuko Fujimoto, Takeshi Suzuki, K. Kawashima

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

1. The depressor response to sodium nitroprusside (SNP) and the presser response to NO-nitro-L-arginine methyl ester (L-NAME) were investigated in anaesthetized and ganglion-blocked 6 week old (young) and 20 week old (adult) spontaneously hypertensive rats (SHR), and the results were compared with those in age-matched normotensive Wistar- Kyoto (WKY) rats. 2. SNP produced a dose-dependent decrease of the mean blood pressure (BP) in both strains, and no differences in vascular sensitivity to SNP were observed between the strains. 3. L-NAME caused dose-dependent presser responses in both strains. The sensitivity and the maximal response to L-NAME in SHR were significantly greater than those in age-matched WKY (P<0.05 or 0.01; t-test, 13 d.f. in both ages). However, there were no significant differences in the responses between ages in each strain. 4. Acute reduction of BP induced by 7-O-ethylfangchinoline did not affect the responses to SNP and L-NAME in the adult SHR. 5. These results indicate that a greater mount of NO is tonically released in SHR and that its contribution to BP control is greater in SHR than in WKY, whereas vascular sensitivity to NO does not differ between the strains. In addition, acute changes in BP do not affect the degree of dependency on NO for BP control.

Original languageEnglish
JournalClinical and Experimental Pharmacology and Physiology
Volume22
Issue numberSUPPL. 1
Publication statusPublished - 1995

Fingerprint

Inbred SHR Rats
NG-Nitroarginine Methyl Ester
Nitroprusside
Young Adult
Nitric Oxide
Blood Pressure
Blood Vessels
Inbred WKY Rats
Ganglia

Keywords

  • 7-O-ethylfangchinoline
  • Mean blood pressure
  • N(ω)-nitro-L-arginine methyl ester
  • Nitric oxide
  • Sodium nitroprusside
  • Spontaneously hypertensive rat
  • Wistar-Kyoto rat

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Role of nitric oxide in the control of blood pressure in young and adult spontaneously hypertensive rats. / Akiba, Y.; Yamaguchi, N.; Amano, H.; Fujii, T.; Fujimoto, Kazuko; Suzuki, Takeshi; Kawashima, K.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 22, No. SUPPL. 1, 1995.

Research output: Contribution to journalArticle

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AU - Suzuki, Takeshi

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