Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

Shingo Kato; Yoshikazu Tsuzuki; Ryota Hokari; Yoshikiyo Okada; Junichi Miyazaki; Koji Matsuzaki; Atsuhiro Iwai; Atsushi Kawaguchi; Shigeaki Nagao; Kazuro Itoh; Hidekazu Suzuki; Toshitaka Nabeshima; Soichiro Miura

doi:10.1016/j.jneuroim.2004.12.006

Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

Shingo Kato, Yoshikazu Tsuzuki, Ryota Hokari, Yoshikiyo Okada, Junichi Miyazaki, Koji Matsuzaki, Atsuhiro Iwai, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Hidekazu Suzuki, Toshitaka Nabeshima, Soichiro Miura

Medical Education Center

Research output: Contribution to journal › Article

23 Citations (Scopus)

Abstract

Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.

Original language	English
Pages (from-to)	21-28
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	161
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.12.006
Publication status	Published - 2005 Apr

Keywords

Adhesion molecule
Colitis
Dextran sulfate sodium
Nociceptin/orphanin FQ

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Kato, S., Tsuzuki, Y., Hokari, R., Okada, Y., Miyazaki, J., Matsuzaki, K., Iwai, A., Kawaguchi, A., Nagao, S., Itoh, K., Suzuki, H., Nabeshima, T., & Miura, S. (2005). Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis. Journal of Neuroimmunology, 161(1-2), 21-28. https://doi.org/10.1016/j.jneuroim.2004.12.006

Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis. / Kato, Shingo; Tsuzuki, Yoshikazu; Hokari, Ryota; Okada, Yoshikiyo; Miyazaki, Junichi; Matsuzaki, Koji; Iwai, Atsuhiro; Kawaguchi, Atsushi; Nagao, Shigeaki; Itoh, Kazuro; Suzuki, Hidekazu; Nabeshima, Toshitaka; Miura, Soichiro.

In: Journal of Neuroimmunology, Vol. 161, No. 1-2, 04.2005, p. 21-28.

Research output: Contribution to journal › Article

Kato, Shingo ; Tsuzuki, Yoshikazu ; Hokari, Ryota ; Okada, Yoshikiyo ; Miyazaki, Junichi ; Matsuzaki, Koji ; Iwai, Atsuhiro ; Kawaguchi, Atsushi ; Nagao, Shigeaki ; Itoh, Kazuro ; Suzuki, Hidekazu ; Nabeshima, Toshitaka ; Miura, Soichiro. / Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis. In: Journal of Neuroimmunology. 2005 ; Vol. 161, No. 1-2. pp. 21-28.

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