Role of pelvic lymph node dissection in lymph node-negative patients with invasive bladder cancer

Suguru Shirotake, Eiji Kikuchi, Kazuhiro Matsumoto, Satoshi Yazawa, Takeo Kosaka, Akira Miyajima, Ken Nakagawa, Mototsugu Oya

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: The role of pelvic lymphadenectomy in patients with lymph node-negative bladder cancer at radical cystectomy (RC) has not yet been examined in detail. We retrospectively reviewed patients who underwent RC with pelvic lymphadenectomy for bladder cancer from January 1987 to March 2008. Methods: We identified consecutive data on 169 patients who underwent RC for bladder cancer. The mean follow-up was 64 months (range: 1-253 months). Node-positive status (pN(+)) was seen in 16 patients and 91 were diagnosed as node-negative (pN(-)). The lymph node status of the remaining 62 patients was unclear (pN(x)). We analysed the association between lymph node status and cancer-specific survival (CSS), and examined the role of the number of retrieved lymph nodes, particularly in pN(-). Results: The median number of retrieved nodes was 12.9 and 10.2 for stage pN(+) and stage pN(-), respectively. In 91 patients with pN(-), multivariate analysis revealed that pathological T3-4 (P = 0.0276) and less than nine retrieved lymph nodes (P = 0.0108) were independent risk factors for CSS. In a subgroup of 83 patients with pT3-4, Kaplan-Meier curves showed that the 5-year CSS rate in pN(-) patients with less than nine retrieved lymph nodes was 38.8%, which was extremely similar to the 40.8% in pN(+) and 45.1% in pN(x). Conclusions: Our results demonstrate that at least nine lymph nodes should be removed to improve the survival of pN(-) patients at RC and lymphadenectomy, and would provide information not only on prognosis but also on the therapeutic impact on pT3-4 invasive bladder cancer.

Original languageEnglish
Article numberhyp147
Pages (from-to)247-251
Number of pages5
JournalJapanese Journal of Clinical Oncology
Volume40
Issue number3
DOIs
Publication statusPublished - 2009 Nov 3

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Lymph Node Excision
Urinary Bladder Neoplasms
Lymph Nodes
Cystectomy
Survival
Neoplasms
Multivariate Analysis
Survival Rate

Keywords

  • Bladder cancer
  • Cystectomy
  • Lymph node dissection
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Role of pelvic lymph node dissection in lymph node-negative patients with invasive bladder cancer. / Shirotake, Suguru; Kikuchi, Eiji; Matsumoto, Kazuhiro; Yazawa, Satoshi; Kosaka, Takeo; Miyajima, Akira; Nakagawa, Ken; Oya, Mototsugu.

In: Japanese Journal of Clinical Oncology, Vol. 40, No. 3, hyp147, 03.11.2009, p. 247-251.

Research output: Contribution to journalArticle

Shirotake, Suguru ; Kikuchi, Eiji ; Matsumoto, Kazuhiro ; Yazawa, Satoshi ; Kosaka, Takeo ; Miyajima, Akira ; Nakagawa, Ken ; Oya, Mototsugu. / Role of pelvic lymph node dissection in lymph node-negative patients with invasive bladder cancer. In: Japanese Journal of Clinical Oncology. 2009 ; Vol. 40, No. 3. pp. 247-251.
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AU - Kosaka, Takeo

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AB - Objectives: The role of pelvic lymphadenectomy in patients with lymph node-negative bladder cancer at radical cystectomy (RC) has not yet been examined in detail. We retrospectively reviewed patients who underwent RC with pelvic lymphadenectomy for bladder cancer from January 1987 to March 2008. Methods: We identified consecutive data on 169 patients who underwent RC for bladder cancer. The mean follow-up was 64 months (range: 1-253 months). Node-positive status (pN(+)) was seen in 16 patients and 91 were diagnosed as node-negative (pN(-)). The lymph node status of the remaining 62 patients was unclear (pN(x)). We analysed the association between lymph node status and cancer-specific survival (CSS), and examined the role of the number of retrieved lymph nodes, particularly in pN(-). Results: The median number of retrieved nodes was 12.9 and 10.2 for stage pN(+) and stage pN(-), respectively. In 91 patients with pN(-), multivariate analysis revealed that pathological T3-4 (P = 0.0276) and less than nine retrieved lymph nodes (P = 0.0108) were independent risk factors for CSS. In a subgroup of 83 patients with pT3-4, Kaplan-Meier curves showed that the 5-year CSS rate in pN(-) patients with less than nine retrieved lymph nodes was 38.8%, which was extremely similar to the 40.8% in pN(+) and 45.1% in pN(x). Conclusions: Our results demonstrate that at least nine lymph nodes should be removed to improve the survival of pN(-) patients at RC and lymphadenectomy, and would provide information not only on prognosis but also on the therapeutic impact on pT3-4 invasive bladder cancer.

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