Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

Shigenori Nagai; Yutaka Kurebayashi; Shigeo Koyasu

doi:10.1111/nyas.12059

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

Shigenori Nagai, Yutaka Kurebayashi, Shigeo Koyasu

Department of Pathology

Research output: Contribution to journal › Article › peer-review

104 Citations (Scopus)

Abstract

Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cascades and a complex network of transcription factors. Recently, it has been shown that PI3K, Akt, and mammalian target of rapamycin (mTOR) complexes, such as mTORC1 and mTORC2, also positively regulate Th17 differentiation both in vivo and in vitro via multiple mechanisms; here, we review the current knowledge regarding the mechanisms through which these molecules enhance Th17 differentiation.

Original language	English
Pages (from-to)	30-34
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1280
Issue number	1
DOIs	https://doi.org/10.1111/nyas.12059
Publication status	Published - 2013 Mar

Keywords

HIF-1
MTOR
PI3K
Th17

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/nyas.12059

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abstract = "Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cascades and a complex network of transcription factors. Recently, it has been shown that PI3K, Akt, and mammalian target of rapamycin (mTOR) complexes, such as mTORC1 and mTORC2, also positively regulate Th17 differentiation both in vivo and in vitro via multiple mechanisms; here, we review the current knowledge regarding the mechanisms through which these molecules enhance Th17 differentiation.",

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AB - Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cascades and a complex network of transcription factors. Recently, it has been shown that PI3K, Akt, and mammalian target of rapamycin (mTOR) complexes, such as mTORC1 and mTORC2, also positively regulate Th17 differentiation both in vivo and in vitro via multiple mechanisms; here, we review the current knowledge regarding the mechanisms through which these molecules enhance Th17 differentiation.

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Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

Abstract

Keywords

ASJC Scopus subject areas

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