Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1

I. Kurose, S. Miura, D. Fukumura, H. Tashiro, H. Imaeda, H. Shiozaki, M. Suematsu, H. Nagata,, E. Sekizuka, M. Tsuchiya

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We have examined the hypothesis that the release-of tissue type plasminogen activator may play a prominent role in endothelin induced gastric mucosal injury. We determined tissue type plasminogen activator activity in the regional blood sample and the concentration of platelet activating factor inthe gastric mucosa after the administration of endothelin-l in a range of 50-500 pmoll kg into the left gastric artery of male Wistar rats. Endothelin-1 increased the tissue type plasminogen activator release and platelet activating factor formation, and induced subsequent gastric mucosal haemorrhagic change in a dose dependent manner. In addition CV-6209, a selective platelet activating factor blocker, attenuated the activation of regional tissue type plasminogen activator and the development of mucosal damage induced by endothelin-1. The results of this study showed that tissue type plasminogen activator activation may play an important role in the pathogenesis of endothelin induced mucosal injury of rat stomach, and suggest that the platelet activating factor may be involved in the process of regional fibrinolytic activation induced by endothelin-1.

Original languageEnglish
Pages (from-to)868-871
Number of pages4
JournalGut
Volume33
Issue number7
DOIs
Publication statusPublished - 1992

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Platelet Activating Factor
Endothelin-1
Tissue Plasminogen Activator
Stomach
Endothelins
Wounds and Injuries
Gastric Mucosa
Wistar Rats
Arteries

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Kurose, I., Miura, S., Fukumura, D., Tashiro, H., Imaeda, H., Shiozaki, H., ... Tsuchiya, M. (1992). Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1. Gut, 33(7), 868-871. https://doi.org/10.1136/gut.33.7.868

Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1. / Kurose, I.; Miura, S.; Fukumura, D.; Tashiro, H.; Imaeda, H.; Shiozaki, H.; Suematsu, M.; Nagata, H.; Sekizuka, E.; Tsuchiya, M.

In: Gut, Vol. 33, No. 7, 1992, p. 868-871.

Research output: Contribution to journalArticle

Kurose, I, Miura, S, Fukumura, D, Tashiro, H, Imaeda, H, Shiozaki, H, Suematsu, M, Nagata, H, Sekizuka, E & Tsuchiya, M 1992, 'Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1', Gut, vol. 33, no. 7, pp. 868-871. https://doi.org/10.1136/gut.33.7.868
Kurose, I. ; Miura, S. ; Fukumura, D. ; Tashiro, H. ; Imaeda, H. ; Shiozaki, H. ; Suematsu, M. ; Nagata, H. ; Sekizuka, E. ; Tsuchiya, M. / Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1. In: Gut. 1992 ; Vol. 33, No. 7. pp. 868-871.
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