Role of reactive metabolites of oxygen and nitrogen in partial liver transplantation: Lessons learned from reduced-size liver ischaemia and reperfusion injury

Hidejiro Urakami, Yuta Abe, Matthew B. Grisham

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant number of patients develop tissue injury from these procedures, ultimately resulting in graft failure. 2. Because of this, there is a real need to understand the different mechanisms responsible for the tissue injury induced by I/R of RSL transplantation (RSL + I/R), with the ultimate goal to develop new and improved therapeutic agents that may limit the tissue damage incurred during RSL transplantation. 3. The present paper reviews the recent studies that have been performed examining the role of reactive metabolites of oxygen and nitrogen in a mouse model of RSL + I/R. In addition, we present data demonstrating how the pathophysiological mechanisms identified in this model compare with those observed in a model of RSL transplantation in rats.

Original languageEnglish
Pages (from-to)912-919
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Volume34
Issue number9
DOIs
Publication statusPublished - 2007 Sep

Keywords

  • Inflammation
  • Leucocytes
  • Liver transplantation
  • Microvasculature
  • NADPH oxidase
  • Nitric oxide
  • Pro-inflammatory cytokines
  • Reactive oxygen species

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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