Role of reelin during layer formation in the cerebralneocortex

Research output: Contribution to journalReview article

Abstract

Reelin controls the neuronal layer formation in the developing cerebral neocortex. The Reelin glycoprotein is mainly secreted from Cajat-Retzius cells in the marginal zone, and it guides the proper aggregation of the migrating neurons in a birth-dependent "inside-out" manner. Reelin also regulates the final process of neuronal migration (terminal translocation and somal translocation) by activating integrin and N-cadherin. It is also expressed around the subventricular zone and it controls the behavior of the migrating neurons.

Original languageEnglish
Pages (from-to)931-937
Number of pages7
JournalBrain and Nerve
Volume68
Issue number8
Publication statusPublished - 2016 Aug 1

    Fingerprint

Keywords

  • Layer formation
  • Neuronal aggregation
  • Primitive cortical zone
  • Reelin
  • Terminal translocation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this