Role of reelin during layer formation in the cerebralneocortex

Research output: Contribution to journalReview article

Abstract

Reelin controls the neuronal layer formation in the developing cerebral neocortex. The Reelin glycoprotein is mainly secreted from Cajat-Retzius cells in the marginal zone, and it guides the proper aggregation of the migrating neurons in a birth-dependent "inside-out" manner. Reelin also regulates the final process of neuronal migration (terminal translocation and somal translocation) by activating integrin and N-cadherin. It is also expressed around the subventricular zone and it controls the behavior of the migrating neurons.

Original languageEnglish
Pages (from-to)931-937
Number of pages7
JournalBrain and Nerve
Volume68
Issue number8
Publication statusPublished - 2016 Aug 1

Fingerprint

Neurons
Behavior Control
Lateral Ventricles
Neocortex
Cadherins
Integrins
Glycoproteins
Parturition

Keywords

  • Layer formation
  • Neuronal aggregation
  • Primitive cortical zone
  • Reelin
  • Terminal translocation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Role of reelin during layer formation in the cerebralneocortex. / Nakajima, Kazunori.

In: Brain and Nerve, Vol. 68, No. 8, 01.08.2016, p. 931-937.

Research output: Contribution to journalReview article

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