Role of serotonin in impaired gas exchange during pulmonary embolism

A. Kawai, A. Umeda, Masaaki Mori, T. Takasugi, K. Asano, T. Tanaka, M. Yasuoka, K. Yamaguchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although serotonin has been reported to play a susbstantial role in cardiopulmonary dysfunction, the quantitative effects of serotonin, released from activated platelets, on the development of alveolar flooding and on impaired gas exchange in pulmonary embolism have not been systematically investigated. To elucidate the effects of serotonin on pulmonary hemodynamics, accumulation of edema fluid in alveolar space, and impairment of gas exchange in acute pulmonary embolism, 20 mongrel dogs were given 0.4- 0.6 g/kg of glass beads with a diameter of 100 μm, via the internal juglar vein. Before and after embolization, pulmonary hemodynamics, systemic hemodynamics, blood gases, and the distribution of ventilation-perfusion ratios (V̇(A)/Q̇) in the lung were measured, with and without a newly developed selective antagonist of the serotonin S2 receptor, DV-7028. V̇(A)/Q̇ distribution was determined by applying the multiple inert gas elimination technique. After glass bead embolization, the animals that did not receive DV-7028 showed significant increases in pulmonary arterial pressure and in extravascular lung water, widened alveolar-arterial O2 tension differences, and appreciable development of low V̇(A)/Q̇ areas (0 < V̇(A)/Q̇ ≤ 0.1). These changes were prevented in the animals that received DV-7028. However, DV-7028 did not affect the formation of high V̇(A)/Q̇ areas (V̇(A)/Q̇ > 10). In conclusion, in acute canine pulmonary embolism serotonin not only induces pulmonary hypertension and pulmonary edema, but also worsens gas exchange through the formation of low V̇(A)/Q̇ areas.

Original languageEnglish
Pages (from-to)947-955
Number of pages9
JournalJapanese Journal of Thoracic Diseases
Volume33
Issue number9
Publication statusPublished - 1995

Fingerprint

Pulmonary Embolism
Serotonin
Gases
Lung
Hemodynamics
Glass
Arterial Pressure
Ventilation-Perfusion Ratio
Serotonin 5-HT2 Receptors
Extravascular Lung Water
Noble Gases
Pulmonary Edema
Pulmonary Hypertension
Canidae
Veins
Edema
Blood Platelets
Dogs
DV 7028

Keywords

  • Extravascular lung water
  • Pulmonary embolism
  • Pulmonary hypertension
  • Serotonin
  • V̇(A)/Q̇ distribution

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Kawai, A., Umeda, A., Mori, M., Takasugi, T., Asano, K., Tanaka, T., ... Yamaguchi, K. (1995). Role of serotonin in impaired gas exchange during pulmonary embolism. Japanese Journal of Thoracic Diseases, 33(9), 947-955.

Role of serotonin in impaired gas exchange during pulmonary embolism. / Kawai, A.; Umeda, A.; Mori, Masaaki; Takasugi, T.; Asano, K.; Tanaka, T.; Yasuoka, M.; Yamaguchi, K.

In: Japanese Journal of Thoracic Diseases, Vol. 33, No. 9, 1995, p. 947-955.

Research output: Contribution to journalArticle

Kawai, A, Umeda, A, Mori, M, Takasugi, T, Asano, K, Tanaka, T, Yasuoka, M & Yamaguchi, K 1995, 'Role of serotonin in impaired gas exchange during pulmonary embolism', Japanese Journal of Thoracic Diseases, vol. 33, no. 9, pp. 947-955.
Kawai A, Umeda A, Mori M, Takasugi T, Asano K, Tanaka T et al. Role of serotonin in impaired gas exchange during pulmonary embolism. Japanese Journal of Thoracic Diseases. 1995;33(9):947-955.
Kawai, A. ; Umeda, A. ; Mori, Masaaki ; Takasugi, T. ; Asano, K. ; Tanaka, T. ; Yasuoka, M. ; Yamaguchi, K. / Role of serotonin in impaired gas exchange during pulmonary embolism. In: Japanese Journal of Thoracic Diseases. 1995 ; Vol. 33, No. 9. pp. 947-955.
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