Role of stem cells in the pathogenesis of endometriosis

Tetsuo Maruyama

doi:10.1007/978-4-431-54421-0_4

Role of stem cells in the pathogenesis of endometriosis

Tetsuo Maruyama

Department of Obstetrics and Gynecology (Obstetrics)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Endometriosis can be defined as a benign estrogen-dependent disorder in which endometrium-like tissues reside outside of the uterine cavity. Studies now indicate that multiple genetic and epigenetic changes (reminiscent of neoplastic processes) are involved in the pathophysiology of endometriosis. Given the molecular similarities between endometriosis and cancer, it is reasonable to apply the cancer stem cell model concept to the pathogenesis of endometriosis. In this article, I review and discuss the stem cell model for endometriosis in which endometriosis originates from endometrial stem/progenitor cells within eutopic and ectopic sites.

Original language	English
Title of host publication	Endometriosis
Subtitle of host publication	Pathogenesis and Treatment
Publisher	Springer Japan
Pages	33-48
Number of pages	16
ISBN (Electronic)	9784431544210
ISBN (Print)	4431544208, 9784431544203
DOIs	https://doi.org/10.1007/978-4-431-54421-0_4
Publication status	Published - 2014 Jan 1

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Keywords

Cancer
Endometriosis
Endometrium
Epithelial-mesenchymal transition
Stem cells

ASJC Scopus subject areas

Medicine(all)

Cite this

Maruyama, T. (2014). Role of stem cells in the pathogenesis of endometriosis. In Endometriosis: Pathogenesis and Treatment (pp. 33-48). Springer Japan. https://doi.org/10.1007/978-4-431-54421-0_4

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Access to Document

10.1007/978-4-431-54421-0_4