Abstract
Endometriosis can be defined as a benign estrogen-dependent disorder in which endometrium-like tissues reside outside of the uterine cavity. Studies now indicate that multiple genetic and epigenetic changes (reminiscent of neoplastic processes) are involved in the pathophysiology of endometriosis. Given the molecular similarities between endometriosis and cancer, it is reasonable to apply the cancer stem cell model concept to the pathogenesis of endometriosis. In this article, I review and discuss the stem cell model for endometriosis in which endometriosis originates from endometrial stem/progenitor cells within eutopic and ectopic sites.
| Original language | English |
|---|---|
| Title of host publication | Endometriosis: Pathogenesis and Treatment |
| Publisher | Springer Japan |
| Pages | 33-48 |
| Number of pages | 16 |
| Volume | 9784431544210 |
| ISBN (Print) | 9784431544210, 4431544208, 9784431544203 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Cancer
- Endometriosis
- Endometrium
- Epithelial-mesenchymal transition
- Stem cells
ASJC Scopus subject areas
- Medicine(all)
Cite this
Role of stem cells in the pathogenesis of endometriosis. / Maruyama, Tetsuo.
Endometriosis: Pathogenesis and Treatment. Vol. 9784431544210 Springer Japan, 2014. p. 33-48.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - Role of stem cells in the pathogenesis of endometriosis
AU - Maruyama, Tetsuo
PY - 2014
Y1 - 2014
N2 - Endometriosis can be defined as a benign estrogen-dependent disorder in which endometrium-like tissues reside outside of the uterine cavity. Studies now indicate that multiple genetic and epigenetic changes (reminiscent of neoplastic processes) are involved in the pathophysiology of endometriosis. Given the molecular similarities between endometriosis and cancer, it is reasonable to apply the cancer stem cell model concept to the pathogenesis of endometriosis. In this article, I review and discuss the stem cell model for endometriosis in which endometriosis originates from endometrial stem/progenitor cells within eutopic and ectopic sites.
AB - Endometriosis can be defined as a benign estrogen-dependent disorder in which endometrium-like tissues reside outside of the uterine cavity. Studies now indicate that multiple genetic and epigenetic changes (reminiscent of neoplastic processes) are involved in the pathophysiology of endometriosis. Given the molecular similarities between endometriosis and cancer, it is reasonable to apply the cancer stem cell model concept to the pathogenesis of endometriosis. In this article, I review and discuss the stem cell model for endometriosis in which endometriosis originates from endometrial stem/progenitor cells within eutopic and ectopic sites.
KW - Cancer
KW - Endometriosis
KW - Endometrium
KW - Epithelial-mesenchymal transition
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=84930690876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930690876&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-54421-0_4
DO - 10.1007/978-4-431-54421-0_4
M3 - Chapter
AN - SCOPUS:84930690876
SN - 9784431544210
SN - 4431544208
SN - 9784431544203
VL - 9784431544210
SP - 33
EP - 48
BT - Endometriosis: Pathogenesis and Treatment
PB - Springer Japan
ER -