Role of stem cells in the pathogenesis of endometriosis

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Endometriosis can be defined as a benign estrogen-dependent disorder in which endometrium-like tissues reside outside of the uterine cavity. Studies now indicate that multiple genetic and epigenetic changes (reminiscent of neoplastic processes) are involved in the pathophysiology of endometriosis. Given the molecular similarities between endometriosis and cancer, it is reasonable to apply the cancer stem cell model concept to the pathogenesis of endometriosis. In this article, I review and discuss the stem cell model for endometriosis in which endometriosis originates from endometrial stem/progenitor cells within eutopic and ectopic sites.

Original languageEnglish
Title of host publicationEndometriosis: Pathogenesis and Treatment
PublisherSpringer Japan
Pages33-48
Number of pages16
Volume9784431544210
ISBN (Print)9784431544210, 4431544208, 9784431544203
DOIs
Publication statusPublished - 2014

Fingerprint

Endometriosis
Stem Cells
Neoplastic Processes
Neoplastic Stem Cells
Endometrium
Epigenomics
Estrogens
Neoplasms

Keywords

  • Cancer
  • Endometriosis
  • Endometrium
  • Epithelial-mesenchymal transition
  • Stem cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Maruyama, T. (2014). Role of stem cells in the pathogenesis of endometriosis. In Endometriosis: Pathogenesis and Treatment (Vol. 9784431544210, pp. 33-48). Springer Japan. https://doi.org/10.1007/978-4-431-54421-0_4

Role of stem cells in the pathogenesis of endometriosis. / Maruyama, Tetsuo.

Endometriosis: Pathogenesis and Treatment. Vol. 9784431544210 Springer Japan, 2014. p. 33-48.

Research output: Chapter in Book/Report/Conference proceedingChapter

Maruyama, T 2014, Role of stem cells in the pathogenesis of endometriosis. in Endometriosis: Pathogenesis and Treatment. vol. 9784431544210, Springer Japan, pp. 33-48. https://doi.org/10.1007/978-4-431-54421-0_4
Maruyama T. Role of stem cells in the pathogenesis of endometriosis. In Endometriosis: Pathogenesis and Treatment. Vol. 9784431544210. Springer Japan. 2014. p. 33-48 https://doi.org/10.1007/978-4-431-54421-0_4
Maruyama, Tetsuo. / Role of stem cells in the pathogenesis of endometriosis. Endometriosis: Pathogenesis and Treatment. Vol. 9784431544210 Springer Japan, 2014. pp. 33-48
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