Role of the Immune System in the Development of the Central Nervous System

Keiko Morimoto, Kazunori Nakajima

Research output: Contribution to journalReview article

Abstract

The central nervous system (CNS) and the immune system are both intricate and highly organized systems that regulate the entire body, with both sharing certain common features in developmental mechanisms and operational modes. It is known that innate immunity-related molecules, such as cytokines, toll-like receptors, the complement family, and acquired immunity-related molecules, such as the major histocompatibility complex and antibody receptors, are also expressed in the brain and play important roles in brain development. Moreover, although the brain has previously been regarded as an immune-privileged site, it is known to contain lymphatic vessels. Not only microglia but also lymphocytes regulate cognition and play a vital role in the formation of neuronal circuits. This review provides an overview of the function of immune cells and immune molecules in the CNS, with particular emphasis on their effect on neural developmental processes.

Original languageEnglish
Article number916
JournalFrontiers in Neuroscience
Volume13
DOIs
Publication statusPublished - 2019 Sep 3

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Immune System
Central Nervous System
Brain
Lymphatic Vessels
Toll-Like Receptors
Microglia
Adaptive Immunity
Major Histocompatibility Complex
Innate Immunity
Cognition
Lymphocytes
Cytokines
Antibodies

Keywords

  • central nervous system
  • complement
  • immune system
  • MHC
  • T cell

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Role of the Immune System in the Development of the Central Nervous System. / Morimoto, Keiko; Nakajima, Kazunori.

In: Frontiers in Neuroscience, Vol. 13, 916, 03.09.2019.

Research output: Contribution to journalReview article

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