Role of the innate immune system in the development of chronic colitis

Takanori Kanai, Ryoichi Iiyama, Takahiro Ishikura, Koji Uraushihara, Teruji Totsuka, Motomi Yamazaki, Tetsuya Nakamura, Mamoru Watanabe

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalJournal of Gastroenterology
Volume37
Issue numberSUPPL. 14
Publication statusPublished - 2002 Nov 1
Externally publishedYes

Fingerprint

Lymphoid Tissue
Colitis
Immune System
Toll-Like Receptors
Inflammatory Bowel Diseases
Innate Immunity
Fermentation
Intestines
Mammals
Bacteria

Keywords

  • Inflammatory bowel disease
  • Innate immunity
  • MyD88
  • Peyer's patch
  • Toll-like receptor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kanai, T., Iiyama, R., Ishikura, T., Uraushihara, K., Totsuka, T., Yamazaki, M., ... Watanabe, M. (2002). Role of the innate immune system in the development of chronic colitis. Journal of Gastroenterology, 37(SUPPL. 14), 38-42.

Role of the innate immune system in the development of chronic colitis. / Kanai, Takanori; Iiyama, Ryoichi; Ishikura, Takahiro; Uraushihara, Koji; Totsuka, Teruji; Yamazaki, Motomi; Nakamura, Tetsuya; Watanabe, Mamoru.

In: Journal of Gastroenterology, Vol. 37, No. SUPPL. 14, 01.11.2002, p. 38-42.

Research output: Contribution to journalArticle

Kanai, T, Iiyama, R, Ishikura, T, Uraushihara, K, Totsuka, T, Yamazaki, M, Nakamura, T & Watanabe, M 2002, 'Role of the innate immune system in the development of chronic colitis', Journal of Gastroenterology, vol. 37, no. SUPPL. 14, pp. 38-42.
Kanai T, Iiyama R, Ishikura T, Uraushihara K, Totsuka T, Yamazaki M et al. Role of the innate immune system in the development of chronic colitis. Journal of Gastroenterology. 2002 Nov 1;37(SUPPL. 14):38-42.
Kanai, Takanori ; Iiyama, Ryoichi ; Ishikura, Takahiro ; Uraushihara, Koji ; Totsuka, Teruji ; Yamazaki, Motomi ; Nakamura, Tetsuya ; Watanabe, Mamoru. / Role of the innate immune system in the development of chronic colitis. In: Journal of Gastroenterology. 2002 ; Vol. 37, No. SUPPL. 14. pp. 38-42.
@article{61bc6fae2cd84efdb53f700aa38faeff,
title = "Role of the innate immune system in the development of chronic colitis",
abstract = "Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).",
keywords = "Inflammatory bowel disease, Innate immunity, MyD88, Peyer's patch, Toll-like receptor",
author = "Takanori Kanai and Ryoichi Iiyama and Takahiro Ishikura and Koji Uraushihara and Teruji Totsuka and Motomi Yamazaki and Tetsuya Nakamura and Mamoru Watanabe",
year = "2002",
month = "11",
day = "1",
language = "English",
volume = "37",
pages = "38--42",
journal = "Journal of Gastroenterology",
issn = "0944-1174",
publisher = "Springer Japan",
number = "SUPPL. 14",

}

TY - JOUR

T1 - Role of the innate immune system in the development of chronic colitis

AU - Kanai, Takanori

AU - Iiyama, Ryoichi

AU - Ishikura, Takahiro

AU - Uraushihara, Koji

AU - Totsuka, Teruji

AU - Yamazaki, Motomi

AU - Nakamura, Tetsuya

AU - Watanabe, Mamoru

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

AB - Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

KW - Inflammatory bowel disease

KW - Innate immunity

KW - MyD88

KW - Peyer's patch

KW - Toll-like receptor

UR - http://www.scopus.com/inward/record.url?scp=0036854676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036854676&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 38

EP - 42

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

IS - SUPPL. 14

ER -