Role of the innate immune system in the development of chronic colitis

Takanori Kanai; Ryoichi Iiyama; Takahiro Ishikura; Koji Uraushihara; Teruji Totsuka; Motomi Yamazaki; Tetsuya Nakamura; Mamoru Watanabe

Role of the innate immune system in the development of chronic colitis

Takanori Kanai, Ryoichi Iiyama, Takahiro Ishikura, Koji Uraushihara, Teruji Totsuka, Motomi Yamazaki, Tetsuya Nakamura, Mamoru Watanabe

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

Original language	English
Pages (from-to)	38-42
Number of pages	5
Journal	Journal of gastroenterology
Volume	37
Issue number	SUPPL. 14
Publication status	Published - 2002 Nov 1
Externally published	Yes

Keywords

Inflammatory bowel disease
Innate immunity
MyD88
Peyer's patch
Toll-like receptor

ASJC Scopus subject areas

Gastroenterology

Cite this

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abstract = "Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).",

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AU - Kanai, Takanori

AU - Iiyama, Ryoichi

AU - Ishikura, Takahiro

AU - Uraushihara, Koji

AU - Totsuka, Teruji

AU - Yamazaki, Motomi

AU - Nakamura, Tetsuya

AU - Watanabe, Mamoru

PY - 2002/11/1

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AB - Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

KW - Inflammatory bowel disease

KW - Innate immunity

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KW - Peyer's patch

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Role of the innate immune system in the development of chronic colitis

Abstract

Keywords

ASJC Scopus subject areas

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