Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism

Hiroyuki Kobori, Atsuhiro Ichihara, Hiromichi Suzuki, Tsuneo Takenaka, Yutaka Miyashita, Matsuhiko Hayashi, Takao Saruta

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

-This study was conducted to examine whether the renin-angiotensin system contributes to hyperthyroidisminduced cardiac hypertrophy without involving the sympathetic nervous system. Sprague-Dawley rats were divided into control-innervated, control-denervated, hyperthyroidinnervated, and hyperthyroid-denervated groups using intraperitoneal injections of thyroxine and 6-hydroxydopamine. After 8 wk, the heart-to-body weight ratio increased in hyperthyroid groups (63%), and this increase was only partially inhibited by sympathetic denervation. Radioimmunoassays and reverse transcription-polymerase chain reaction revealed increased cardiac levels of renin (33%) and angiotensin II (53%) and enhanced cardiac expression of renin mRNA (225%) in the hyperthyroid groups. These increases were unaffected by sympathetic denervation or 24-h bilateral nephrectomy. In addition, losartan and nicardipine decreased systolic blood pressure to the same extent, but only losartan caused regression of thyroxine-induced cardiac hypertrophy. These results suggest that thyroid hormone activates the cardiac renin-angiotensin system without involving the sympathetic nervous system or the circulating renin-angiotensin system; the activated renin-angiotensin system contributes to cardiac hypertrophy in hyperthyroidism. chemical sympathectomy; polymerase chain reaction; tissue renin; angiotensin II type 1 receptor antagonist

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume42
Issue number2
Publication statusPublished - 1997

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Cardiomegaly
Hyperthyroidism
Renin-Angiotensin System
Renin
Sympathectomy
Losartan
Sympathetic Nervous System
Thyroxine
Chemical Sympathectomy
Blood Pressure
Angiotensin II Type 1 Receptor Blockers
Nicardipine
Polymerase Chain Reaction
Oxidopamine
Intraperitoneal Injections
Nephrectomy
Thyroid Hormones
Angiotensin II
Reverse Transcription
Radioimmunoassay

ASJC Scopus subject areas

  • Physiology

Cite this

Kobori, H., Ichihara, A., Suzuki, H., Takenaka, T., Miyashita, Y., Hayashi, M., & Saruta, T. (1997). Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. American Journal of Physiology - Heart and Circulatory Physiology, 42(2).

Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. / Kobori, Hiroyuki; Ichihara, Atsuhiro; Suzuki, Hiromichi; Takenaka, Tsuneo; Miyashita, Yutaka; Hayashi, Matsuhiko; Saruta, Takao.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 42, No. 2, 1997.

Research output: Contribution to journalArticle

Kobori, H, Ichihara, A, Suzuki, H, Takenaka, T, Miyashita, Y, Hayashi, M & Saruta, T 1997, 'Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism', American Journal of Physiology - Heart and Circulatory Physiology, vol. 42, no. 2.
Kobori, Hiroyuki ; Ichihara, Atsuhiro ; Suzuki, Hiromichi ; Takenaka, Tsuneo ; Miyashita, Yutaka ; Hayashi, Matsuhiko ; Saruta, Takao. / Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. In: American Journal of Physiology - Heart and Circulatory Physiology. 1997 ; Vol. 42, No. 2.
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