Role of vagal control in vasovagal syncope

Masaru Suzuki, Shingo Hori, Iwao Nakamura, Shinya Nagata, Yutaka Tomita, Naoki Aikawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The vasovagal reaction is thought to be caused by sympathetic withdrawal and vagal augmentation. While measurements of muscle sympathetic nerve activity support sympathetic withdrawal in tilt induced syncope, the results of previous attempts to quantify vagal control using spectral analyses of heart rate variability (HRV) remain controversial. The sampling period used in the HRV studies is related to the discordant results. In the present study, HRV was computed every second using wavelet transformation to clarify the role of vagal control in tilt induced syncope during the 80-degree head-up tilt test (positive: 10 patients with vasovagal syncope; negative: 10 patients with vasovagal syncope, and 10 control subjects). Autonomic modulations were assessed using the absolute power of the low frequency (LF) (0.04-0.15 Hz) and high frequency (HF) (0.15-2.00 Hz) oscillatory components of R-R variability. Although the LF did not change during the tilt procedure, a decrease in the systolic arterial pressure (SAP) and increases in the R-R interval and HF were observed for the last 30 seconds before the tilt induced syncope in the tilt-positive group. Analyzing the hemodynamic measurements and spectral indices for the last 5 minutes preceding the tilt induced syncope, the study found that the SAP, R-R interval, and HF changed simultaneously during the 30-second period immediately before the tilt induced syncope. Further, the HF was positively correlated with the R-R interval and negatively correlated with the SAP. In conclusion, continuous spectral analysis of the R-R interval demonstrated increased vagal influence on the heart in tilt induced syncope.

Original languageEnglish
Pages (from-to)571-578
Number of pages8
JournalPACE - Pacing and Clinical Electrophysiology
Volume26
Issue number2 I
Publication statusPublished - 2003 Feb 1

Fingerprint

Vasovagal Syncope
Syncope
Arterial Pressure
Heart Rate
Blood Pressure
Hemodynamics
Head
Muscles

Keywords

  • Autonomic nervous system
  • Head-up tilt test
  • Spectral analysis
  • Vasovagal syncope
  • Wavelet transformation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Suzuki, M., Hori, S., Nakamura, I., Nagata, S., Tomita, Y., & Aikawa, N. (2003). Role of vagal control in vasovagal syncope. PACE - Pacing and Clinical Electrophysiology, 26(2 I), 571-578.

Role of vagal control in vasovagal syncope. / Suzuki, Masaru; Hori, Shingo; Nakamura, Iwao; Nagata, Shinya; Tomita, Yutaka; Aikawa, Naoki.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 26, No. 2 I, 01.02.2003, p. 571-578.

Research output: Contribution to journalArticle

Suzuki, M, Hori, S, Nakamura, I, Nagata, S, Tomita, Y & Aikawa, N 2003, 'Role of vagal control in vasovagal syncope', PACE - Pacing and Clinical Electrophysiology, vol. 26, no. 2 I, pp. 571-578.
Suzuki M, Hori S, Nakamura I, Nagata S, Tomita Y, Aikawa N. Role of vagal control in vasovagal syncope. PACE - Pacing and Clinical Electrophysiology. 2003 Feb 1;26(2 I):571-578.
Suzuki, Masaru ; Hori, Shingo ; Nakamura, Iwao ; Nagata, Shinya ; Tomita, Yutaka ; Aikawa, Naoki. / Role of vagal control in vasovagal syncope. In: PACE - Pacing and Clinical Electrophysiology. 2003 ; Vol. 26, No. 2 I. pp. 571-578.
@article{bd125e0fa6744ca389e4618b837c28c2,
title = "Role of vagal control in vasovagal syncope",
abstract = "The vasovagal reaction is thought to be caused by sympathetic withdrawal and vagal augmentation. While measurements of muscle sympathetic nerve activity support sympathetic withdrawal in tilt induced syncope, the results of previous attempts to quantify vagal control using spectral analyses of heart rate variability (HRV) remain controversial. The sampling period used in the HRV studies is related to the discordant results. In the present study, HRV was computed every second using wavelet transformation to clarify the role of vagal control in tilt induced syncope during the 80-degree head-up tilt test (positive: 10 patients with vasovagal syncope; negative: 10 patients with vasovagal syncope, and 10 control subjects). Autonomic modulations were assessed using the absolute power of the low frequency (LF) (0.04-0.15 Hz) and high frequency (HF) (0.15-2.00 Hz) oscillatory components of R-R variability. Although the LF did not change during the tilt procedure, a decrease in the systolic arterial pressure (SAP) and increases in the R-R interval and HF were observed for the last 30 seconds before the tilt induced syncope in the tilt-positive group. Analyzing the hemodynamic measurements and spectral indices for the last 5 minutes preceding the tilt induced syncope, the study found that the SAP, R-R interval, and HF changed simultaneously during the 30-second period immediately before the tilt induced syncope. Further, the HF was positively correlated with the R-R interval and negatively correlated with the SAP. In conclusion, continuous spectral analysis of the R-R interval demonstrated increased vagal influence on the heart in tilt induced syncope.",
keywords = "Autonomic nervous system, Head-up tilt test, Spectral analysis, Vasovagal syncope, Wavelet transformation",
author = "Masaru Suzuki and Shingo Hori and Iwao Nakamura and Shinya Nagata and Yutaka Tomita and Naoki Aikawa",
year = "2003",
month = "2",
day = "1",
language = "English",
volume = "26",
pages = "571--578",
journal = "PACE - Pacing and Clinical Electrophysiology",
issn = "0147-8389",
publisher = "Wiley-Blackwell",
number = "2 I",

}

TY - JOUR

T1 - Role of vagal control in vasovagal syncope

AU - Suzuki, Masaru

AU - Hori, Shingo

AU - Nakamura, Iwao

AU - Nagata, Shinya

AU - Tomita, Yutaka

AU - Aikawa, Naoki

PY - 2003/2/1

Y1 - 2003/2/1

N2 - The vasovagal reaction is thought to be caused by sympathetic withdrawal and vagal augmentation. While measurements of muscle sympathetic nerve activity support sympathetic withdrawal in tilt induced syncope, the results of previous attempts to quantify vagal control using spectral analyses of heart rate variability (HRV) remain controversial. The sampling period used in the HRV studies is related to the discordant results. In the present study, HRV was computed every second using wavelet transformation to clarify the role of vagal control in tilt induced syncope during the 80-degree head-up tilt test (positive: 10 patients with vasovagal syncope; negative: 10 patients with vasovagal syncope, and 10 control subjects). Autonomic modulations were assessed using the absolute power of the low frequency (LF) (0.04-0.15 Hz) and high frequency (HF) (0.15-2.00 Hz) oscillatory components of R-R variability. Although the LF did not change during the tilt procedure, a decrease in the systolic arterial pressure (SAP) and increases in the R-R interval and HF were observed for the last 30 seconds before the tilt induced syncope in the tilt-positive group. Analyzing the hemodynamic measurements and spectral indices for the last 5 minutes preceding the tilt induced syncope, the study found that the SAP, R-R interval, and HF changed simultaneously during the 30-second period immediately before the tilt induced syncope. Further, the HF was positively correlated with the R-R interval and negatively correlated with the SAP. In conclusion, continuous spectral analysis of the R-R interval demonstrated increased vagal influence on the heart in tilt induced syncope.

AB - The vasovagal reaction is thought to be caused by sympathetic withdrawal and vagal augmentation. While measurements of muscle sympathetic nerve activity support sympathetic withdrawal in tilt induced syncope, the results of previous attempts to quantify vagal control using spectral analyses of heart rate variability (HRV) remain controversial. The sampling period used in the HRV studies is related to the discordant results. In the present study, HRV was computed every second using wavelet transformation to clarify the role of vagal control in tilt induced syncope during the 80-degree head-up tilt test (positive: 10 patients with vasovagal syncope; negative: 10 patients with vasovagal syncope, and 10 control subjects). Autonomic modulations were assessed using the absolute power of the low frequency (LF) (0.04-0.15 Hz) and high frequency (HF) (0.15-2.00 Hz) oscillatory components of R-R variability. Although the LF did not change during the tilt procedure, a decrease in the systolic arterial pressure (SAP) and increases in the R-R interval and HF were observed for the last 30 seconds before the tilt induced syncope in the tilt-positive group. Analyzing the hemodynamic measurements and spectral indices for the last 5 minutes preceding the tilt induced syncope, the study found that the SAP, R-R interval, and HF changed simultaneously during the 30-second period immediately before the tilt induced syncope. Further, the HF was positively correlated with the R-R interval and negatively correlated with the SAP. In conclusion, continuous spectral analysis of the R-R interval demonstrated increased vagal influence on the heart in tilt induced syncope.

KW - Autonomic nervous system

KW - Head-up tilt test

KW - Spectral analysis

KW - Vasovagal syncope

KW - Wavelet transformation

UR - http://www.scopus.com/inward/record.url?scp=0037305144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037305144&partnerID=8YFLogxK

M3 - Article

C2 - 12710316

AN - SCOPUS:0037305144

VL - 26

SP - 571

EP - 578

JO - PACE - Pacing and Clinical Electrophysiology

JF - PACE - Pacing and Clinical Electrophysiology

SN - 0147-8389

IS - 2 I

ER -