Role of Wnt Signaling in Mouse Fetal Skin Wound Healing

Kento Takaya, Ayano Sunohara, Noriko Aramaki-hattori, Shigeki Sakai, Keisuke Okabe, Hideko Kanazawa, Toru Asou, Kazuo Kishi

Research output: Contribution to journalArticlepeer-review

Abstract

Wnt proteins secrete glycoproteins that are involved in various cellular processes to main-tain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented. Our previous studies have shown that, in an early-stage mouse fetus, no scarring occurred after cutaneous wounding, and complete regeneration was achieved. In this study, the expression and localization of Wnt proteins in a mouse fetal-wound-healing model and their associations with scar formation were analyzed. Wnt-related molecules were detected by in-situ hybridization, immunostaining, and real-time polymerase chain reaction. The results showed altered expression of Wnt-related molecules during the wound-healing process. Moreover, scar formation was suppressed by Wnt inhibitors, suggesting that Wnt signaling may be involved in wound healing and scar formation. Thus, regulation of Wnt signaling may be a possible mechanism to control scar formation.

Original languageEnglish
Article number1536
JournalBiomedicines
Volume10
Issue number7
DOIs
Publication statusPublished - 2022 Jul

Keywords

  • regeneration
  • scar formation
  • Wnt signalling

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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