Roles of aquaporins in brain disorders

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aquaporin (AQP) is a water channel protein that is expressed in the cell membranes. AQPs are related to several kinds of human diseases such as cataract. In the mammalian central nervous system (CNS), AQP4 is specifically expressed in the astrocyte membranes lining the perivascular and periventricular structures. AQP4 plays a role in the development of brain edema associated with certain brain disorders. Neuromyelitis optica (NMO) is a demyelinating disorder, and patients with NMO develop autoimmune antibodies against AQP4 in their serum. Therefore, AQP4 is involved in NMO pathogenesis. A new concept referred to as "glymphatic pathway" has been recently proposed to explain the lymphatic system in the CNS. Dysfunction of the "glymphatic pathway" may cause several neurodegenerative diseases and mood disorders. Importantly, AQP4 may play a role in the "glymphatic pathway". Further investigation of AQP4 in CNS disorders is necessary, and a new drug against AQP4 is expected.

Original languageEnglish
Pages (from-to)733-738
Number of pages6
JournalBrain and Nerve
Volume67
Issue number6
Publication statusPublished - 2015 Jun 1

Fingerprint

Neuromyelitis Optica
Aquaporins
Brain Diseases
Neurodegenerative Diseases
Central Nervous System
Lymphatic System
Central Nervous System Diseases
Brain Edema
Demyelinating Diseases
Mood Disorders
Astrocytes
Cataract
Cell Membrane
Membranes
Antibodies
Serum
Pharmaceutical Preparations

Keywords

  • Aquaporin
  • Brain edema
  • Glia
  • Glymphatic pathway
  • Neuromyelytis optica

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Roles of aquaporins in brain disorders. / Yasui, Masato.

In: Brain and Nerve, Vol. 67, No. 6, 01.06.2015, p. 733-738.

Research output: Contribution to journalArticle

Yasui, M 2015, 'Roles of aquaporins in brain disorders', Brain and Nerve, vol. 67, no. 6, pp. 733-738.
Yasui, Masato. / Roles of aquaporins in brain disorders. In: Brain and Nerve. 2015 ; Vol. 67, No. 6. pp. 733-738.
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