Roles of cerebrovascular innervations and their neurotransmitters in various pathological conditions of central nervous system

Norihiro Suzuki

Research output: Contribution to journalArticle

Abstract

The concept of neurogenic control of the cerebral circulation began to develop only as recent as the middle of the 20th century, when it was elucidated that the cerebral blood vessels are supplied by a very dense plexus of adrenergic nerves innervating the vascular bed. After then, already in the course of several decades, more than ten types of neurotransimitters including acetylcholine, serotonin, substance P, and calcitonin gene-related peptide, etc., have been observed in these nerves. To determine the origins and pathways of cerebrovascular parasympathetic nerves and sensory nerves, retrograde axonal tracing with immnohistochemstry has been studied. The cerebrovascular parasympathetic nerves originated 1) in the sphenopalatine ganglion (SPG), and 2) from the internal carotid ganglion, and also 3) from the otic ganglion. While the cerebrovascular sensory nerves originated 1) in the trigeminal ganglion (TG), and 2) from the internal carotid ganglion, and also 3) from the upper cervical dorsal root ganglia. The neurogenic cerebrovascular vasodilatation was demonstrated in vivo, by the electrical stimulation of the cerebraovascular branches of TG or SPG. This vasodilatation was attenuated not by anticholinergic agents but triptans as well as anti-CGRP agents. This implicates the mechanism of pathological neurogenic inflammation and vasodilatation during the migraine attacks.

Original languageEnglish
Pages (from-to)819-824
Number of pages6
JournalClinical Neurology
Volume52
Issue number11
DOIs
Publication statusPublished - 2012

Fingerprint

Ganglia
Neurotransmitter Agents
Central Nervous System
Vasodilation
Trigeminal Ganglion
Blood Vessels
Cerebrovascular Circulation
Parasympathetic Ganglia
Neurogenic Inflammation
Tryptamines
Calcitonin Gene-Related Peptide
Cholinergic Antagonists
Spinal Ganglia
Substance P
Migraine Disorders
Adrenergic Agents
Electric Stimulation
Acetylcholine
Serotonin

Keywords

  • Cortical spreading depression
  • Innervations of cerebral blood vessels
  • Migraine
  • Parasympathetic nerve
  • Trigeminal nerve

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Roles of cerebrovascular innervations and their neurotransmitters in various pathological conditions of central nervous system. / Suzuki, Norihiro.

In: Clinical Neurology, Vol. 52, No. 11, 2012, p. 819-824.

Research output: Contribution to journalArticle

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