Roles of cytokines and T cells in the pathogenesis of myasthenia gravis

A. Uzawa, S. Kuwabara, S. Suzuki, T. Imai, H. Murai, Y. Ozawa, M. Yasuda, Y. Nagane, K. Utsugisawa

Research output: Contribution to journalReview articlepeer-review

Abstract

Myasthenia gravis (MG) is characterized by muscle weakness and fatigue caused by the presence of autoantibodies against the acetylcholine receptor (AChR) or the muscle-specific tyrosine kinase (MuSK). Activated T, B and plasma cells, as well as cytokines, play important roles in the production of pathogenic autoantibodies and the induction of inflammation at the neuromuscular junction in MG. Many studies have focused on the role of cytokines and lymphocytes in anti-AChR antibody-positive MG. Chronic inflammation mediated by T helper type 17 (Th17) cells, the promotion of autoantibody production from B cells and plasma cells by follicular Th (Tfh) cells and the activation of the immune response by dysfunction of regulatory T (Treg) cells may contribute to the exacerbation of the MG pathogenesis. In fact, an increased number of Th17 cells and Tfh cells and dysfunction of Treg cells have been reported in patients with anti-AChR antibody-positive MG; moreover, the number of these cells was correlated with clinical parameters in patients with MG. Regarding cytokines, interleukin (IL)-17; a Th17-related cytokine, IL-21 (a Tfh-related cytokine), the B-cell-activating factor (BAFF; a B cell-related cytokine) and a proliferation-inducing ligand (APRIL; a B cell-related cytokine) have been reported to be up-regulated and associated with clinical parameters of MG. This review focuses on the current understanding of the involvement of cytokines and lymphocytes in the immunological pathogenesis of MG, which may lead to the development of novel therapies for this disease in the near future.

Original languageEnglish
Pages (from-to)366-374
Number of pages9
JournalClinical and Experimental Immunology
Volume203
Issue number3
DOIs
Publication statusPublished - 2021 Mar

Keywords

  • B cell
  • cytokine
  • lymphocyte
  • myasthenia gravis
  • treatment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Roles of cytokines and T cells in the pathogenesis of myasthenia gravis'. Together they form a unique fingerprint.

Cite this