Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Keiyo Takubo, Toshio Suda

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Stem cells exhibit a number of characteristic features, including the capacity for self-renewal and differentiation into multiple cell types, stress resistance, and drug efflux activity. These specific biological characteristics are supported by signals from the surrounding niche and the stemcell-specific transcription factor set, including hypoxia and the machinery that senses low oxygen levels. These properties are essential for normal stem cells, and when defective may induce cellular senescence and tumorigenesis. In contrast, cancer stem cells in tumor tissue utilize these biological characters driven by stemcell-specific molecular mechanisms and acquire indefinite selfrenewal capacity, drug resistance, and metastatic ability. A fuller understanding of the differences between normal and malignant stem cells in the biological and molecular context is, therefore, necessary to the development of therapies against cancer stem cells. In this review, we discuss the effect of hypoxic microenvironment on normal and malignant stem cells and describe their molecular machinery with an emphasis on hematopoietic stem cells and their malignant counterparts, leukemic stem cells.

Original languageEnglish
Pages (from-to)478-483
Number of pages6
JournalInternational Journal of Hematology
Volume95
Issue number5
DOIs
Publication statusPublished - 2012 May

Fingerprint

Hematopoietic Stem Cells
Stem Cells
Neoplastic Stem Cells
Drug Resistance
Cell Aging
Carcinogenesis
Transcription Factors
Hypoxia
Oxygen
Neoplasms
Therapeutics

Keywords

  • Hematopoietic stem cell
  • Hypoxia
  • Leukemic stem cell
  • Stem cell niche

ASJC Scopus subject areas

  • Hematology

Cite this

Roles of the hypoxia response system in hematopoietic and leukemic stem cells. / Takubo, Keiyo; Suda, Toshio.

In: International Journal of Hematology, Vol. 95, No. 5, 05.2012, p. 478-483.

Research output: Contribution to journalArticle

Takubo, Keiyo ; Suda, Toshio. / Roles of the hypoxia response system in hematopoietic and leukemic stem cells. In: International Journal of Hematology. 2012 ; Vol. 95, No. 5. pp. 478-483.
@article{aa678250e6a140039d41f581992bae1d,
title = "Roles of the hypoxia response system in hematopoietic and leukemic stem cells",
abstract = "Stem cells exhibit a number of characteristic features, including the capacity for self-renewal and differentiation into multiple cell types, stress resistance, and drug efflux activity. These specific biological characteristics are supported by signals from the surrounding niche and the stemcell-specific transcription factor set, including hypoxia and the machinery that senses low oxygen levels. These properties are essential for normal stem cells, and when defective may induce cellular senescence and tumorigenesis. In contrast, cancer stem cells in tumor tissue utilize these biological characters driven by stemcell-specific molecular mechanisms and acquire indefinite selfrenewal capacity, drug resistance, and metastatic ability. A fuller understanding of the differences between normal and malignant stem cells in the biological and molecular context is, therefore, necessary to the development of therapies against cancer stem cells. In this review, we discuss the effect of hypoxic microenvironment on normal and malignant stem cells and describe their molecular machinery with an emphasis on hematopoietic stem cells and their malignant counterparts, leukemic stem cells.",
keywords = "Hematopoietic stem cell, Hypoxia, Leukemic stem cell, Stem cell niche",
author = "Keiyo Takubo and Toshio Suda",
year = "2012",
month = "5",
doi = "10.1007/s12185-012-1071-4",
language = "English",
volume = "95",
pages = "478--483",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "5",

}

TY - JOUR

T1 - Roles of the hypoxia response system in hematopoietic and leukemic stem cells

AU - Takubo, Keiyo

AU - Suda, Toshio

PY - 2012/5

Y1 - 2012/5

N2 - Stem cells exhibit a number of characteristic features, including the capacity for self-renewal and differentiation into multiple cell types, stress resistance, and drug efflux activity. These specific biological characteristics are supported by signals from the surrounding niche and the stemcell-specific transcription factor set, including hypoxia and the machinery that senses low oxygen levels. These properties are essential for normal stem cells, and when defective may induce cellular senescence and tumorigenesis. In contrast, cancer stem cells in tumor tissue utilize these biological characters driven by stemcell-specific molecular mechanisms and acquire indefinite selfrenewal capacity, drug resistance, and metastatic ability. A fuller understanding of the differences between normal and malignant stem cells in the biological and molecular context is, therefore, necessary to the development of therapies against cancer stem cells. In this review, we discuss the effect of hypoxic microenvironment on normal and malignant stem cells and describe their molecular machinery with an emphasis on hematopoietic stem cells and their malignant counterparts, leukemic stem cells.

AB - Stem cells exhibit a number of characteristic features, including the capacity for self-renewal and differentiation into multiple cell types, stress resistance, and drug efflux activity. These specific biological characteristics are supported by signals from the surrounding niche and the stemcell-specific transcription factor set, including hypoxia and the machinery that senses low oxygen levels. These properties are essential for normal stem cells, and when defective may induce cellular senescence and tumorigenesis. In contrast, cancer stem cells in tumor tissue utilize these biological characters driven by stemcell-specific molecular mechanisms and acquire indefinite selfrenewal capacity, drug resistance, and metastatic ability. A fuller understanding of the differences between normal and malignant stem cells in the biological and molecular context is, therefore, necessary to the development of therapies against cancer stem cells. In this review, we discuss the effect of hypoxic microenvironment on normal and malignant stem cells and describe their molecular machinery with an emphasis on hematopoietic stem cells and their malignant counterparts, leukemic stem cells.

KW - Hematopoietic stem cell

KW - Hypoxia

KW - Leukemic stem cell

KW - Stem cell niche

UR - http://www.scopus.com/inward/record.url?scp=84862894073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862894073&partnerID=8YFLogxK

U2 - 10.1007/s12185-012-1071-4

DO - 10.1007/s12185-012-1071-4

M3 - Article

C2 - 22539363

AN - SCOPUS:84862894073

VL - 95

SP - 478

EP - 483

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 5

ER -