Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells

Takashi Sekiya, Hiroko Nakatsukasa, Qianjin Lu, Akihiko Yoshimura

Research output: Contribution to journalArticle

15 Citations (Scopus)


Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.

Original languageEnglish
JournalMicrobes and Infection
Publication statusAccepted/In press - 2016 Feb 15



  • Clostridium species
  • DNA methylation
  • Foxp3
  • Regulatory T cell
  • TGF-β
  • Transcription factors

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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