Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells

Takashi Sekiya; Hiroko Nakatsukasa; Qianjin Lu; Akihiko Yoshimura

doi:10.1016/j.micinf.2016.02.004

Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells

Takashi Sekiya, Hiroko Nakatsukasa, Qianjin Lu, Akihiko Yoshimura

Department of Microbiology and Immunology

Research output: Contribution to journal › Short survey › peer-review

28 Citations (Scopus)

Abstract

Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.

Original language	English
Pages (from-to)	378-386
Number of pages	9
Journal	Microbes and Infection
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/j.micinf.2016.02.004
Publication status	Published - 2016 Jun 1

Keywords

Clostridium species
DNA methylation
Foxp3
Regulatory T cell
TGF-β
Transcription factors

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2016.02.004

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title = "Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells",

abstract = "Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.",

keywords = "Clostridium species, DNA methylation, Foxp3, Regulatory T cell, TGF-β, Transcription factors",

author = "Takashi Sekiya and Hiroko Nakatsukasa and Qianjin Lu and Akihiko Yoshimura",

note = "Funding Information: This work was supported by JSPS KAKENHI Grant-in-Aid for Young Scientists (A) and (S) No. 25221305 , Advanced Research & Development Programs for Medical Innovation (AMED-CREST), the Takeda Science Foundation , the Uehara Memorial Foundation , the Mochida Memorial Foundation for Medical and Pharmaceutical Research , the Kanae Foundation , and the SENSHIN Medical Research Foundation , Keio Gijuku Academic Developmental Funds . Publisher Copyright: {\textcopyright} 2016 Institut Pasteur Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.micinf.2016.02.004",

language = "English",

volume = "18",

pages = "378--386",

journal = "Microbes and Infection",

issn = "1286-4579",

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number = "6",

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TY - JOUR

T1 - Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells

AU - Sekiya, Takashi

AU - Nakatsukasa, Hiroko

AU - Lu, Qianjin

AU - Yoshimura, Akihiko

N1 - Funding Information: This work was supported by JSPS KAKENHI Grant-in-Aid for Young Scientists (A) and (S) No. 25221305 , Advanced Research & Development Programs for Medical Innovation (AMED-CREST), the Takeda Science Foundation , the Uehara Memorial Foundation , the Mochida Memorial Foundation for Medical and Pharmaceutical Research , the Kanae Foundation , and the SENSHIN Medical Research Foundation , Keio Gijuku Academic Developmental Funds . Publisher Copyright: © 2016 Institut Pasteur Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.

AB - Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.

KW - Clostridium species

KW - DNA methylation

KW - Foxp3

KW - Regulatory T cell

KW - TGF-β

KW - Transcription factors

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UR - http://www.scopus.com/inward/citedby.url?scp=84962129105&partnerID=8YFLogxK

U2 - 10.1016/j.micinf.2016.02.004

DO - 10.1016/j.micinf.2016.02.004

M3 - Short survey

C2 - 26970203

AN - SCOPUS:84962129105

SN - 1286-4579

VL - 18

SP - 378

EP - 386

JO - Microbes and Infection

JF - Microbes and Infection

IS - 6

ER -

Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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