Rosette forming cells, surface immunoglobulin bearing cells and immunoglobulin containing cells in the thymus of autoimmune diseases

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Abstract

The present study was intended to clarify histological and immunological characteristics of the thymus removed from 174 cases with a variety of autoimmune diseases. Thymic lymphoid follicles were demonstrated in 115 out of 174 cases (66.1%) of autoimmune diseases, but only in 12 out of 71 (16.9%) among accidental death cases used as controls. Thymus derived cell population of thymic lymphocytes in autoimmune diseases tended to be slightly less than in congenital heart disease cases used as controls. The author obtained little response with stimulation by phytohemagglutinin, in the majority of the cases. Bone marrow derived cell population with surface immunoglobulin as the marker, ranged from 0 to 17% in 25 cases. It was proved that the thymic lymphoid follicles and the presence of surface immunoglobulin bearing cells in thymic lymphocytes were in close correlation. Immunoglobulin containing cells which were morphologically similar to plasma cells were found in high incidence in autoimmune diseases. At the present time, the author considers that both surface immunoglobulin bearing cells and immunoglobulin containing cells are in the same lineage and immunoglobulin containing cells differentiated from surface immunoglobulin bearing cells. The antibody to thymus was found in 14 out of 59 cases (23.4%), and it was proved that positive cases with the antibody to thymus were correlated to the presence of immunoglobulin containing cells in the thymus.

Original languageEnglish
Pages (from-to)297-310
Number of pages14
JournalKeio Journal of Medicine
Volume24
Issue number4
Publication statusPublished - 1975

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B-Cell Antigen Receptors
Thymus Gland
Autoimmune Diseases
Immunoglobulins
Lymphocytes
Antibodies
Phytohemagglutinins
Plasma Cells
Bone Marrow Cells
Population
Heart Diseases
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Rosette forming cells, surface immunoglobulin bearing cells and immunoglobulin containing cells in the thymus of autoimmune diseases",
abstract = "The present study was intended to clarify histological and immunological characteristics of the thymus removed from 174 cases with a variety of autoimmune diseases. Thymic lymphoid follicles were demonstrated in 115 out of 174 cases (66.1{\%}) of autoimmune diseases, but only in 12 out of 71 (16.9{\%}) among accidental death cases used as controls. Thymus derived cell population of thymic lymphocytes in autoimmune diseases tended to be slightly less than in congenital heart disease cases used as controls. The author obtained little response with stimulation by phytohemagglutinin, in the majority of the cases. Bone marrow derived cell population with surface immunoglobulin as the marker, ranged from 0 to 17{\%} in 25 cases. It was proved that the thymic lymphoid follicles and the presence of surface immunoglobulin bearing cells in thymic lymphocytes were in close correlation. Immunoglobulin containing cells which were morphologically similar to plasma cells were found in high incidence in autoimmune diseases. At the present time, the author considers that both surface immunoglobulin bearing cells and immunoglobulin containing cells are in the same lineage and immunoglobulin containing cells differentiated from surface immunoglobulin bearing cells. The antibody to thymus was found in 14 out of 59 cases (23.4{\%}), and it was proved that positive cases with the antibody to thymus were correlated to the presence of immunoglobulin containing cells in the thymus.",
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T1 - Rosette forming cells, surface immunoglobulin bearing cells and immunoglobulin containing cells in the thymus of autoimmune diseases

AU - Yoshida, Tadashi

PY - 1975

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N2 - The present study was intended to clarify histological and immunological characteristics of the thymus removed from 174 cases with a variety of autoimmune diseases. Thymic lymphoid follicles were demonstrated in 115 out of 174 cases (66.1%) of autoimmune diseases, but only in 12 out of 71 (16.9%) among accidental death cases used as controls. Thymus derived cell population of thymic lymphocytes in autoimmune diseases tended to be slightly less than in congenital heart disease cases used as controls. The author obtained little response with stimulation by phytohemagglutinin, in the majority of the cases. Bone marrow derived cell population with surface immunoglobulin as the marker, ranged from 0 to 17% in 25 cases. It was proved that the thymic lymphoid follicles and the presence of surface immunoglobulin bearing cells in thymic lymphocytes were in close correlation. Immunoglobulin containing cells which were morphologically similar to plasma cells were found in high incidence in autoimmune diseases. At the present time, the author considers that both surface immunoglobulin bearing cells and immunoglobulin containing cells are in the same lineage and immunoglobulin containing cells differentiated from surface immunoglobulin bearing cells. The antibody to thymus was found in 14 out of 59 cases (23.4%), and it was proved that positive cases with the antibody to thymus were correlated to the presence of immunoglobulin containing cells in the thymus.

AB - The present study was intended to clarify histological and immunological characteristics of the thymus removed from 174 cases with a variety of autoimmune diseases. Thymic lymphoid follicles were demonstrated in 115 out of 174 cases (66.1%) of autoimmune diseases, but only in 12 out of 71 (16.9%) among accidental death cases used as controls. Thymus derived cell population of thymic lymphocytes in autoimmune diseases tended to be slightly less than in congenital heart disease cases used as controls. The author obtained little response with stimulation by phytohemagglutinin, in the majority of the cases. Bone marrow derived cell population with surface immunoglobulin as the marker, ranged from 0 to 17% in 25 cases. It was proved that the thymic lymphoid follicles and the presence of surface immunoglobulin bearing cells in thymic lymphocytes were in close correlation. Immunoglobulin containing cells which were morphologically similar to plasma cells were found in high incidence in autoimmune diseases. At the present time, the author considers that both surface immunoglobulin bearing cells and immunoglobulin containing cells are in the same lineage and immunoglobulin containing cells differentiated from surface immunoglobulin bearing cells. The antibody to thymus was found in 14 out of 59 cases (23.4%), and it was proved that positive cases with the antibody to thymus were correlated to the presence of immunoglobulin containing cells in the thymus.

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