RRR-alpha-tocopherol, the most biologically active form of vitamin E, is a lipid soluble antioxidant that protects membranes from oxidative stresses. Vitamin E occurs in nature in eight different forms, but the body is enriched in RRR-alpha-tocopherol compared with other forms. Studies on the transport of vitamin E in animals and humans suggest that the liver plays a key role in the preferential retention, and subsequent distribution of RRR-alpha-tocopherol to tissues. We have purified RRR-alpha-tocopherol transfer protein (alpha-TTP) from the liver and cloned its cDNA. alpha-TTP specifically binds RRR-alpha-tocopherol and enhances its transfer between membranes. Furthermore, we have identified that alpha-TTP is abnormal in the patients with familial isolated vitamin E deficiency. The nature and physiological functions of alpha-TTP will be reviewed.
|Publication status||Published - 1998 Mar 20|
ASJC Scopus subject areas
- Molecular Biology