TY - JOUR
T1 - rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts
AU - Fuku, Noriyuki
AU - Díaz-Peña, Roberto
AU - Arai, Yasumichi
AU - Abe, Yukiko
AU - Pareja-Galeano, Helios
AU - Sanchis-Gomar, Fabián
AU - Santos-Lozano, Alejandro
AU - Zempo, Hirofumi
AU - Naito, Hisashi
AU - Murakami, Haruka
AU - Miyachi, Motohiko
AU - Venturini, Letizia
AU - Ricevuti, Giovanni
AU - Nobuyoshi, Hirose
AU - Emanuele, Enzo
AU - Lucia, Alejandro
N1 - Funding Information:
This work was supported by grants from the Grant-in-Aid for Scientific Research (B) ( 15H03081 to N.F.) program of the Ministry of Education, Culture, Sports, Science and Technology and by a grant-in-aid for scientific research from the Ministry of Health, Labor, and Welfare of Japan (to M.M.). HZ was a recipient of Grant-in-Aid for JSPS Fellows from the Japan Society for the Promotion of Science . Research by AL and HP-G is funded by grants from Fondo de Investigaciones Sanitarias (FIS, grants # PI12/00914 and PI15/00558 ) and Fondos FEDER .
Publisher Copyright:
© 2016
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Objectives Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting. Study design and main outcome measures Using a case-control design, we investigated the distribution of the rs2802292 polymorphism in two ethnically distinct cohorts of centenarians (cases) and younger adults (controls). The first cohort included Japanese individuals (733 centenarians and 820 controls) and the second was from Northern Italy (79 disease-free centenarians and 316 controls). Results No statistically significant association was found between the rs2802292 polymorphism and EL in either cohort (either examined in their entirety or in a sex-based analysis). Conclusions In light of our negative findings, further research and resequencing efforts are needed to shed more light on the potential association between EL and FOXO3A polymorphisms.
AB - Objectives Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting. Study design and main outcome measures Using a case-control design, we investigated the distribution of the rs2802292 polymorphism in two ethnically distinct cohorts of centenarians (cases) and younger adults (controls). The first cohort included Japanese individuals (733 centenarians and 820 controls) and the second was from Northern Italy (79 disease-free centenarians and 316 controls). Results No statistically significant association was found between the rs2802292 polymorphism and EL in either cohort (either examined in their entirety or in a sex-based analysis). Conclusions In light of our negative findings, further research and resequencing efforts are needed to shed more light on the potential association between EL and FOXO3A polymorphisms.
KW - Aging
KW - Centenarian
KW - FOXO3A
KW - Genetics
KW - Longevity
KW - Polymorphism
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U2 - 10.1016/j.maturitas.2016.07.016
DO - 10.1016/j.maturitas.2016.07.016
M3 - Article
C2 - 27621247
AN - SCOPUS:84982856697
SN - 0378-5122
VL - 92
SP - 110
EP - 114
JO - Maturitas
JF - Maturitas
ER -
