rugose (rg), a drosophila a kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways

Hoda K. Shamloula, Mkajiuna P. Mbogho, Angel C. Pimentel, Zosia M A Chrzanowska-Lightowlers, Vanneta Hyatt, Hideyuki Okano, Tadmiri R. Venkatesh

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In the developing Drosophila eye, cell fate determination and pattern formation are directed by cell-cell interactions mediated by signal transduction cascades. Mutations at the rugose locus (rg) result in a rough eye phenotype due to a disorganized retina and aberrant cone cell differentiation, which leads to reduction or complete loss of cone cells. The cone cell phenotype is sensitive to the level of rugose gene function. Molecular analyses show that rugose encodes a Drosophila A kinase anchor protein (DAKAP 550). Genetic interaction studies show that rugose interacts with the components of the EGFR- and Notch-mediated signaling pathways. Our results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways.

Original languageEnglish
Pages (from-to)693-710
Number of pages18
JournalGenetics
Volume161
Issue number2
Publication statusPublished - 2002

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Protein Kinases
Drosophila
Retinal Cone Photoreceptor Cells
Phenotype
Cell Communication
Cell Differentiation
Signal Transduction
Mutation
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Shamloula, H. K., Mbogho, M. P., Pimentel, A. C., Chrzanowska-Lightowlers, Z. M. A., Hyatt, V., Okano, H., & Venkatesh, T. R. (2002). rugose (rg), a drosophila a kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. Genetics, 161(2), 693-710.

rugose (rg), a drosophila a kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. / Shamloula, Hoda K.; Mbogho, Mkajiuna P.; Pimentel, Angel C.; Chrzanowska-Lightowlers, Zosia M A; Hyatt, Vanneta; Okano, Hideyuki; Venkatesh, Tadmiri R.

In: Genetics, Vol. 161, No. 2, 2002, p. 693-710.

Research output: Contribution to journalArticle

Shamloula, HK, Mbogho, MP, Pimentel, AC, Chrzanowska-Lightowlers, ZMA, Hyatt, V, Okano, H & Venkatesh, TR 2002, 'rugose (rg), a drosophila a kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways', Genetics, vol. 161, no. 2, pp. 693-710.
Shamloula, Hoda K. ; Mbogho, Mkajiuna P. ; Pimentel, Angel C. ; Chrzanowska-Lightowlers, Zosia M A ; Hyatt, Vanneta ; Okano, Hideyuki ; Venkatesh, Tadmiri R. / rugose (rg), a drosophila a kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. In: Genetics. 2002 ; Vol. 161, No. 2. pp. 693-710.
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AU - Pimentel, Angel C.

AU - Chrzanowska-Lightowlers, Zosia M A

AU - Hyatt, Vanneta

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AU - Venkatesh, Tadmiri R.

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