Ruthenium-catalyzed C-H/CO/olefin coupling reaction of N-arylpyrazoles. Extraordinary reactivity of N-arylpyrazoles toward carbonylation at C-H bonds

Taku Asaumi, Naoto Chatani, Takuya Matsuo, Fumitoshi Kakiuchi, Shinji Murai

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The reaction of 1-arylpyrazoles with CO and ethylene in the presence of Ru3(CO)12 resulted in regioselective carbonylation at the ortho C-H bonds. While it is found that the pyrazole ring also functions as the directing group for C-H bond cleavage, the efficiency of the reaction depends on the position of the pyrazole ring.

Original languageEnglish
Pages (from-to)7538-7540
Number of pages3
JournalJournal of Organic Chemistry
Volume68
Issue number19
Publication statusPublished - 2003 Sep 19
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

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