Ruthenium-catalyzed cycloisomerization and its application to the synthesis of (±)-cinchonaminone

Takao Ogawa, Tomonori Nakamura, Takuya Araki, Koujirou Yamamoto, Satoshi Shuto, Mitsuhiro Arisawa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ru-catalyzed cycloisomerization of a 1,3-diene and the alkene of an N-dienyl-2-vinylaniline substrate proceeded smoothly, leading to a 3-exomethylene-2-vinylindole derivative in good yield. This useful synthon was successfully applied to the total synthesis of (±)-cinchonaminone.

Original languageEnglish
Pages (from-to)3084-3087
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number16
DOIs
Publication statusPublished - 2012 Jun 1
Externally publishedYes

Keywords

  • Cyclization
  • Heterocycles
  • Natural products
  • Ruthenium
  • Total synthesis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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