Ruthenium-Catalyzed Ortho C-H Arylation of Aromatic Nitriles with Arylboronates and Observation of Partial Para Arylation

Yuta Koseki, Kentaroh Kitazawa, Masashi Miyake, Takuya Kochi, Fumitoshi Kakiuchi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ruthenium-catalyzed C-H arylation of aromatic nitriles with arylboronates is described. The use of RuH2(CO){P(4-MeC6H4)3}3 as a catalyst provided higher yields of the ortho arylation products than the conventional RuH2(CO)(PPh3)3 catalyst. The arylation takes place mostly at the ortho positions, but unprecedented para arylation was also partially observed to give ortho,para diarylation products. In addition to C-H bond cleavage, the cyano group was also found to function as a directing group for cleavage of C-O bonds in aryl ethers.

Original languageEnglish
Pages (from-to)6503-6510
Number of pages8
JournalJournal of Organic Chemistry
Volume82
Issue number13
DOIs
Publication statusPublished - 2017 Jul 7

    Fingerprint

ASJC Scopus subject areas

  • Organic Chemistry

Cite this