Ruthenium-catalyzed reductive deamination and tandem alkylation of aniline derivatives

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20 Citations (Scopus)

Abstract

We developed two new catalytic transformations of anilines via oxidative addition of CeN bonds to ruthenium centers. One is ruthenium-catalyzed reductive deaminatoindeamination of N-alkylated oacylanilines. The other one is catalytic coupling of N-alkylated o-acylanilines with olefins giving orthoalkylated aromatic ketones via CeN bond cleavage. This reaction involves a ruthenium hydride species as an intermediate, formed after b-hydride elimination from the ruthenium amide species.

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalJournal of Organometallic Chemistry
Volume741-742
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Keywords

  • Carbonenitrogen bond cleavage
  • Deamination
  • Ruthenium catalyst
  • Tandem deamination/alkylation

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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