Abstract
The ruthenium-catalyzed hydroarylation of alkynes with benzamides proceeds regio- and stereoselectively through a directed C-H bond cleavage. Preliminary mechanistic investigations indicate that the reaction involves amide-directed ortho-metalation, carbometalation of alkyne, and protonolysis. Similarly, phenylazoles also add to alkynes regioselectively.
| Original language | English |
|---|---|
| Pages (from-to) | 2058-2061 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 14 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2012 Apr 20 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Hashimoto, Y., Hirano, K., Satoh, T., Kakiuchi, F., & Miura, M. (2012). Ruthenium(II)-catalyzed regio- and stereoselective hydroarylation of alkynes via directed C-H functionalization. Organic Letters, 14(8), 2058-2061. https://doi.org/10.1021/ol300579m