Abstract
The ruthenium-catalyzed hydroarylation of alkynes with benzamides proceeds regio- and stereoselectively through a directed C-H bond cleavage. Preliminary mechanistic investigations indicate that the reaction involves amide-directed ortho-metalation, carbometalation of alkyne, and protonolysis. Similarly, phenylazoles also add to alkynes regioselectively.
Original language | English |
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Pages (from-to) | 2058-2061 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2012 Apr 20 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry