Safer endoscopic gastric mucosal resection: Preoperative proton pump inhibitor administration

Yoshiyuki Watanabe, Naoyuki Kato, Tadateru Maehata, Masaru Okamoto, Takashi Tsuda, Santa Hattori, Shunichi Yamauchi, Kazuhiko Fujita, Satoshi Baba, Shinichi Nakaya, Hiroyuki Inaba, Satoshi Kitajima, Michihiro Suzuki, Hirohumi Niwa, Fumio Itoh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background and Aim: Control of bleeding is crucial in improving the safety of endoscopic mucosal resection (EMR), and intragastric acidity has a great impact on hemostasis and blood coagulation. Proton pump inhibitors (PPI) are potent suppressors of gastric acid; however, PPI need to be continuously administered orally for several days, and thus initial effects may be insufficient if PPI is only administered immediately after EMR. The aim of this study was to determine whether preoperative administration of PPI prior to EMR can elevate intragastric acidity, facilitate better control of intraoperative bleeding (complete coagulation and hemostasis), prevent postoperative bleeding, and facilitate healing of artificial ulcers. Methods: A randomized clinical study was conducted in which EMR was performed with or without 1 week of preoperative PPI administration. Results: Artificial ulcers created by EMR healed more rapidly in patients who received preoperative PPI. Conclusions: The results of the study suggest that preoperative administration of PPI before EMR is useful for controlling and preventing bleeding, and for facilitating the healing of artificial ulcers.

Original languageEnglish
Pages (from-to)1675-1680
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume21
Issue number11
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Proton Pump Inhibitors
Stomach
Hemorrhage
Ulcer
Hemostasis
Gastric Acid
Blood Coagulation
Endoscopic Mucosal Resection
Safety

Keywords

  • Complication
  • Endoscopic mucosal resection
  • Intragastric acidity
  • Proton pump inhibitors
  • Ulceration

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Safer endoscopic gastric mucosal resection : Preoperative proton pump inhibitor administration. / Watanabe, Yoshiyuki; Kato, Naoyuki; Maehata, Tadateru; Okamoto, Masaru; Tsuda, Takashi; Hattori, Santa; Yamauchi, Shunichi; Fujita, Kazuhiko; Baba, Satoshi; Nakaya, Shinichi; Inaba, Hiroyuki; Kitajima, Satoshi; Suzuki, Michihiro; Niwa, Hirohumi; Itoh, Fumio.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 21, No. 11, 2006, p. 1675-1680.

Research output: Contribution to journalArticle

Watanabe, Y, Kato, N, Maehata, T, Okamoto, M, Tsuda, T, Hattori, S, Yamauchi, S, Fujita, K, Baba, S, Nakaya, S, Inaba, H, Kitajima, S, Suzuki, M, Niwa, H & Itoh, F 2006, 'Safer endoscopic gastric mucosal resection: Preoperative proton pump inhibitor administration', Journal of Gastroenterology and Hepatology (Australia), vol. 21, no. 11, pp. 1675-1680. https://doi.org/10.1111/j.1440-1746.2006.04467.x
Watanabe, Yoshiyuki ; Kato, Naoyuki ; Maehata, Tadateru ; Okamoto, Masaru ; Tsuda, Takashi ; Hattori, Santa ; Yamauchi, Shunichi ; Fujita, Kazuhiko ; Baba, Satoshi ; Nakaya, Shinichi ; Inaba, Hiroyuki ; Kitajima, Satoshi ; Suzuki, Michihiro ; Niwa, Hirohumi ; Itoh, Fumio. / Safer endoscopic gastric mucosal resection : Preoperative proton pump inhibitor administration. In: Journal of Gastroenterology and Hepatology (Australia). 2006 ; Vol. 21, No. 11. pp. 1675-1680.
@article{e4e1bf1de91a4296a031df84850198e3,
title = "Safer endoscopic gastric mucosal resection: Preoperative proton pump inhibitor administration",
abstract = "Background and Aim: Control of bleeding is crucial in improving the safety of endoscopic mucosal resection (EMR), and intragastric acidity has a great impact on hemostasis and blood coagulation. Proton pump inhibitors (PPI) are potent suppressors of gastric acid; however, PPI need to be continuously administered orally for several days, and thus initial effects may be insufficient if PPI is only administered immediately after EMR. The aim of this study was to determine whether preoperative administration of PPI prior to EMR can elevate intragastric acidity, facilitate better control of intraoperative bleeding (complete coagulation and hemostasis), prevent postoperative bleeding, and facilitate healing of artificial ulcers. Methods: A randomized clinical study was conducted in which EMR was performed with or without 1 week of preoperative PPI administration. Results: Artificial ulcers created by EMR healed more rapidly in patients who received preoperative PPI. Conclusions: The results of the study suggest that preoperative administration of PPI before EMR is useful for controlling and preventing bleeding, and for facilitating the healing of artificial ulcers.",
keywords = "Complication, Endoscopic mucosal resection, Intragastric acidity, Proton pump inhibitors, Ulceration",
author = "Yoshiyuki Watanabe and Naoyuki Kato and Tadateru Maehata and Masaru Okamoto and Takashi Tsuda and Santa Hattori and Shunichi Yamauchi and Kazuhiko Fujita and Satoshi Baba and Shinichi Nakaya and Hiroyuki Inaba and Satoshi Kitajima and Michihiro Suzuki and Hirohumi Niwa and Fumio Itoh",
year = "2006",
doi = "10.1111/j.1440-1746.2006.04467.x",
language = "English",
volume = "21",
pages = "1675--1680",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Safer endoscopic gastric mucosal resection

T2 - Preoperative proton pump inhibitor administration

AU - Watanabe, Yoshiyuki

AU - Kato, Naoyuki

AU - Maehata, Tadateru

AU - Okamoto, Masaru

AU - Tsuda, Takashi

AU - Hattori, Santa

AU - Yamauchi, Shunichi

AU - Fujita, Kazuhiko

AU - Baba, Satoshi

AU - Nakaya, Shinichi

AU - Inaba, Hiroyuki

AU - Kitajima, Satoshi

AU - Suzuki, Michihiro

AU - Niwa, Hirohumi

AU - Itoh, Fumio

PY - 2006

Y1 - 2006

N2 - Background and Aim: Control of bleeding is crucial in improving the safety of endoscopic mucosal resection (EMR), and intragastric acidity has a great impact on hemostasis and blood coagulation. Proton pump inhibitors (PPI) are potent suppressors of gastric acid; however, PPI need to be continuously administered orally for several days, and thus initial effects may be insufficient if PPI is only administered immediately after EMR. The aim of this study was to determine whether preoperative administration of PPI prior to EMR can elevate intragastric acidity, facilitate better control of intraoperative bleeding (complete coagulation and hemostasis), prevent postoperative bleeding, and facilitate healing of artificial ulcers. Methods: A randomized clinical study was conducted in which EMR was performed with or without 1 week of preoperative PPI administration. Results: Artificial ulcers created by EMR healed more rapidly in patients who received preoperative PPI. Conclusions: The results of the study suggest that preoperative administration of PPI before EMR is useful for controlling and preventing bleeding, and for facilitating the healing of artificial ulcers.

AB - Background and Aim: Control of bleeding is crucial in improving the safety of endoscopic mucosal resection (EMR), and intragastric acidity has a great impact on hemostasis and blood coagulation. Proton pump inhibitors (PPI) are potent suppressors of gastric acid; however, PPI need to be continuously administered orally for several days, and thus initial effects may be insufficient if PPI is only administered immediately after EMR. The aim of this study was to determine whether preoperative administration of PPI prior to EMR can elevate intragastric acidity, facilitate better control of intraoperative bleeding (complete coagulation and hemostasis), prevent postoperative bleeding, and facilitate healing of artificial ulcers. Methods: A randomized clinical study was conducted in which EMR was performed with or without 1 week of preoperative PPI administration. Results: Artificial ulcers created by EMR healed more rapidly in patients who received preoperative PPI. Conclusions: The results of the study suggest that preoperative administration of PPI before EMR is useful for controlling and preventing bleeding, and for facilitating the healing of artificial ulcers.

KW - Complication

KW - Endoscopic mucosal resection

KW - Intragastric acidity

KW - Proton pump inhibitors

KW - Ulceration

UR - http://www.scopus.com/inward/record.url?scp=33748792524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748792524&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1746.2006.04467.x

DO - 10.1111/j.1440-1746.2006.04467.x

M3 - Article

C2 - 16984588

AN - SCOPUS:33748792524

VL - 21

SP - 1675

EP - 1680

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 11

ER -