Safety and Effectiveness of Tolvaptan Administration after Total Arch Replacement

Yasunori Iida, Akihiro Yoshitake, Hideyuki Shimizu

Research output: Contribution to journalArticle

Abstract

Background: Postoperative fluid overload in cardiovascular surgery is associated with increased mortality and morbidity. Recently, tolvaptan (TLV), a selective vasopressin V2 antagonist, has been used for perioperative fluid management. This study aimed to validate the safety and effectiveness of TLV administration after total arch replacement (TAR) using selective cerebral perfusion. Methods: From August 2016 to December 2016, 11 patients who had undergone TAR for thoracic aortic aneurysm were included in this study. In addition to the conventional diuretics furosemide (20 mg) and spironolactone (25 mg), TLV (7.5 mg) was administered orally. Results: TLV increased urine output 1-3 days after administration. Body weight was gradually and steadily reduced until discharge. Neither renal nor liver dysfunction was recognized during the TLV administration. Conclusion: The concomitant use of TLV and conventional diuretics is safe and effective for fluid management after TAR using cardiopulmonary bypass, selective cerebral perfusion, and hypothermic circulatory arrest.

Original languageEnglish
JournalAnnals of Vascular Surgery
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Safety
Diuretics
Perfusion
Thoracic Aortic Aneurysm
Spironolactone
Furosemide
Cardiopulmonary Bypass
tolvaptan
Liver Diseases
Body Weight
Urine
Morbidity
Kidney
Mortality

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Safety and Effectiveness of Tolvaptan Administration after Total Arch Replacement. / Iida, Yasunori; Yoshitake, Akihiro; Shimizu, Hideyuki.

In: Annals of Vascular Surgery, 01.01.2018.

Research output: Contribution to journalArticle

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