Safety and feasibility of radiofrequency ablation using bipolar electrodes for aldosterone-producing adenoma: a multicentric prospective clinical study

Sota Oguro, Ryo Morimoto, Kazumasa Seiji, Hideki Ota, Tomo Kinoshita, Masahiro Kawabata, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Fumitoshi Satoh, Sadayoshi Ito, Nobukazu Moriya, Seishi Matsui, Tetsuo Nishikawa, Masao Omura, Kazuki Nakai, Seishi Nakatsuka, Isao Kurihara, Kazutoshi Miyashita, Wataru KodaTetsuya Minami, Yoshiyu Takeda, Mitsuhiro Kometani, Yutaka Oki, Toshihiro Oishi, Takasuke Ushio, Satoshi Goshima, Kei Takase

Research output: Contribution to journalArticlepeer-review

Abstract

Evaluation of feasibility and safety of percutaneous radiofrequency ablation using bipolar radiofrequency devices in a prospective multicenter cohort of patients with benign aldosterone-producing adenoma. A total of five institutions participated. CT-guided percutaneous RFA was performed for patients diagnosed as APA. The safety of the procedure was evaluated using the Common Terminology Criteria for Adverse Events. During the 84-day follow-up period, serial changes in plasma aldosterone concentration and plasma renin activity were measured. The percentage of patients with normalized hormonal activity after the procedure, was calculated with 95% confidence intervals. Forty patients were enrolled, and two patients were excluded for cerebral hemorrhage and no safe puncture root. In another patients, RFA was tried, but an intraprocedural intercostal arterial injury occurred. Consequently, RFA was completed in thirty-seven patients (20 men, 17 women; mean age, 50.4 ± 10.0 year). The tumor size was 14.8 ± 3.8 mm. The treatment success rate of the ablation was 94.6% (35/37), and a 2nd session was performed in 2.7% (1/37) patients. Grade 4 adverse events were observed in 4 out of 38 sessions (10.5%). The normalization of plasma aldosterone concentration or aldosterone-renin ratio was 86.5% (72.0–94.1: 95% confidence interval) on day 84. Percutaneous CT-guided RFA for APA using a bipolar radiofrequency system was safe and feasible with clinical success rate of 86.5% on day 84.

Original languageEnglish
Article number14090
JournalScientific reports
Volume12
Issue number1
DOIs
Publication statusPublished - 2022 Dec

ASJC Scopus subject areas

  • General

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