Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: A 24-mo prospective multicenter cohort study

T. Morozumi, Taneaki Nakagawa, Y. Nomura, T. Sugaya, M. Kawanami, F. Suzuki, K. Takahashi, Y. Abe, S. Sato, A. Makino-Oi, A. Saito, S. Takano, M. Minabe, Y. Nakayama, Y. Ogata, H. Kobayashi, Y. Izumi, N. Sugano, K. Ito, S. SekinoY. Numabe, C. Fukaya, N. Yoshinari, M. Fukuda, T. Noguchi, T. Kono, M. Umeda, O. Fujise, F. Nishimura, A. Yoshimura, Y. Hara, T. Nakamura, K. Noguchi, E. Kakuta, N. Hanada, S. Takashiba, H. Yoshie

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Objective: A diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. The aim of this multicenter study was to monitor disease progression in patients with chronic periodontitis during a 24-mo follow-up program and to evaluate the amount of bacteria in saliva and corresponding IgG titers in serum for determining the diagnostic usefulness of each in indicating disease progression and stability. Material and Methods: A total of 163 patients with chronic periodontitis who received trimonthly follow-up care were observed for 24 mo. The clinical parameters and salivary content of Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans were assessed using the modified Invader PLUS assay, and the corresponding serum IgG titers were measured using ELISA. The changes through 24 mo were analyzed using cut-off values calculated for each factor. One-way ANOVA or Fisher's exact test was used to perform between-group comparison for the data collected. Diagnostic values were calculated using Fisher's exact test. Results: Of the 124 individuals who completed the 24-mo monitoring phase, 62 exhibited periodontitis progression, whereas 62 demonstrated stable disease. Seven patients withdrew because of acute periodontal abscess. The ratio of P. gingivalis to total bacteria and the combination of P. gingivalis counts and IgG titers against P. gingivalis were significantly related to the progression of periodontitis.

Original languageEnglish
JournalJournal of Periodontal Research
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Chronic Periodontitis
Porphyromonas gingivalis
Multicenter Studies
Periodontitis
Cohort Studies
Antibodies
Immunoglobulin G
Serum
Disease Progression
Periodontal Abscess
Prevotella intermedia
Bacteria
Aggregatibacter actinomycetemcomitans
Aftercare
Saliva
Analysis of Variance
Enzyme-Linked Immunosorbent Assay

Keywords

  • Porphyromonas gingivalis
  • Periodontal stability
  • Periodontitis progression
  • Saliva

ASJC Scopus subject areas

  • Periodontics

Cite this

Salivary pathogen and serum antibody to assess the progression of chronic periodontitis : A 24-mo prospective multicenter cohort study. / Morozumi, T.; Nakagawa, Taneaki; Nomura, Y.; Sugaya, T.; Kawanami, M.; Suzuki, F.; Takahashi, K.; Abe, Y.; Sato, S.; Makino-Oi, A.; Saito, A.; Takano, S.; Minabe, M.; Nakayama, Y.; Ogata, Y.; Kobayashi, H.; Izumi, Y.; Sugano, N.; Ito, K.; Sekino, S.; Numabe, Y.; Fukaya, C.; Yoshinari, N.; Fukuda, M.; Noguchi, T.; Kono, T.; Umeda, M.; Fujise, O.; Nishimura, F.; Yoshimura, A.; Hara, Y.; Nakamura, T.; Noguchi, K.; Kakuta, E.; Hanada, N.; Takashiba, S.; Yoshie, H.

In: Journal of Periodontal Research, 2016.

Research output: Contribution to journalArticle

Morozumi, T, Nakagawa, T, Nomura, Y, Sugaya, T, Kawanami, M, Suzuki, F, Takahashi, K, Abe, Y, Sato, S, Makino-Oi, A, Saito, A, Takano, S, Minabe, M, Nakayama, Y, Ogata, Y, Kobayashi, H, Izumi, Y, Sugano, N, Ito, K, Sekino, S, Numabe, Y, Fukaya, C, Yoshinari, N, Fukuda, M, Noguchi, T, Kono, T, Umeda, M, Fujise, O, Nishimura, F, Yoshimura, A, Hara, Y, Nakamura, T, Noguchi, K, Kakuta, E, Hanada, N, Takashiba, S & Yoshie, H 2016, 'Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: A 24-mo prospective multicenter cohort study', Journal of Periodontal Research. https://doi.org/10.1111/jre.12353
Morozumi, T. ; Nakagawa, Taneaki ; Nomura, Y. ; Sugaya, T. ; Kawanami, M. ; Suzuki, F. ; Takahashi, K. ; Abe, Y. ; Sato, S. ; Makino-Oi, A. ; Saito, A. ; Takano, S. ; Minabe, M. ; Nakayama, Y. ; Ogata, Y. ; Kobayashi, H. ; Izumi, Y. ; Sugano, N. ; Ito, K. ; Sekino, S. ; Numabe, Y. ; Fukaya, C. ; Yoshinari, N. ; Fukuda, M. ; Noguchi, T. ; Kono, T. ; Umeda, M. ; Fujise, O. ; Nishimura, F. ; Yoshimura, A. ; Hara, Y. ; Nakamura, T. ; Noguchi, K. ; Kakuta, E. ; Hanada, N. ; Takashiba, S. ; Yoshie, H. / Salivary pathogen and serum antibody to assess the progression of chronic periodontitis : A 24-mo prospective multicenter cohort study. In: Journal of Periodontal Research. 2016.
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abstract = "Background and Objective: A diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. The aim of this multicenter study was to monitor disease progression in patients with chronic periodontitis during a 24-mo follow-up program and to evaluate the amount of bacteria in saliva and corresponding IgG titers in serum for determining the diagnostic usefulness of each in indicating disease progression and stability. Material and Methods: A total of 163 patients with chronic periodontitis who received trimonthly follow-up care were observed for 24 mo. The clinical parameters and salivary content of Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans were assessed using the modified Invader PLUS assay, and the corresponding serum IgG titers were measured using ELISA. The changes through 24 mo were analyzed using cut-off values calculated for each factor. One-way ANOVA or Fisher's exact test was used to perform between-group comparison for the data collected. Diagnostic values were calculated using Fisher's exact test. Results: Of the 124 individuals who completed the 24-mo monitoring phase, 62 exhibited periodontitis progression, whereas 62 demonstrated stable disease. Seven patients withdrew because of acute periodontal abscess. The ratio of P. gingivalis to total bacteria and the combination of P. gingivalis counts and IgG titers against P. gingivalis were significantly related to the progression of periodontitis.",
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T1 - Salivary pathogen and serum antibody to assess the progression of chronic periodontitis

T2 - A 24-mo prospective multicenter cohort study

AU - Morozumi, T.

AU - Nakagawa, Taneaki

AU - Nomura, Y.

AU - Sugaya, T.

AU - Kawanami, M.

AU - Suzuki, F.

AU - Takahashi, K.

AU - Abe, Y.

AU - Sato, S.

AU - Makino-Oi, A.

AU - Saito, A.

AU - Takano, S.

AU - Minabe, M.

AU - Nakayama, Y.

AU - Ogata, Y.

AU - Kobayashi, H.

AU - Izumi, Y.

AU - Sugano, N.

AU - Ito, K.

AU - Sekino, S.

AU - Numabe, Y.

AU - Fukaya, C.

AU - Yoshinari, N.

AU - Fukuda, M.

AU - Noguchi, T.

AU - Kono, T.

AU - Umeda, M.

AU - Fujise, O.

AU - Nishimura, F.

AU - Yoshimura, A.

AU - Hara, Y.

AU - Nakamura, T.

AU - Noguchi, K.

AU - Kakuta, E.

AU - Hanada, N.

AU - Takashiba, S.

AU - Yoshie, H.

PY - 2016

Y1 - 2016

N2 - Background and Objective: A diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. The aim of this multicenter study was to monitor disease progression in patients with chronic periodontitis during a 24-mo follow-up program and to evaluate the amount of bacteria in saliva and corresponding IgG titers in serum for determining the diagnostic usefulness of each in indicating disease progression and stability. Material and Methods: A total of 163 patients with chronic periodontitis who received trimonthly follow-up care were observed for 24 mo. The clinical parameters and salivary content of Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans were assessed using the modified Invader PLUS assay, and the corresponding serum IgG titers were measured using ELISA. The changes through 24 mo were analyzed using cut-off values calculated for each factor. One-way ANOVA or Fisher's exact test was used to perform between-group comparison for the data collected. Diagnostic values were calculated using Fisher's exact test. Results: Of the 124 individuals who completed the 24-mo monitoring phase, 62 exhibited periodontitis progression, whereas 62 demonstrated stable disease. Seven patients withdrew because of acute periodontal abscess. The ratio of P. gingivalis to total bacteria and the combination of P. gingivalis counts and IgG titers against P. gingivalis were significantly related to the progression of periodontitis.

AB - Background and Objective: A diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. The aim of this multicenter study was to monitor disease progression in patients with chronic periodontitis during a 24-mo follow-up program and to evaluate the amount of bacteria in saliva and corresponding IgG titers in serum for determining the diagnostic usefulness of each in indicating disease progression and stability. Material and Methods: A total of 163 patients with chronic periodontitis who received trimonthly follow-up care were observed for 24 mo. The clinical parameters and salivary content of Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans were assessed using the modified Invader PLUS assay, and the corresponding serum IgG titers were measured using ELISA. The changes through 24 mo were analyzed using cut-off values calculated for each factor. One-way ANOVA or Fisher's exact test was used to perform between-group comparison for the data collected. Diagnostic values were calculated using Fisher's exact test. Results: Of the 124 individuals who completed the 24-mo monitoring phase, 62 exhibited periodontitis progression, whereas 62 demonstrated stable disease. Seven patients withdrew because of acute periodontal abscess. The ratio of P. gingivalis to total bacteria and the combination of P. gingivalis counts and IgG titers against P. gingivalis were significantly related to the progression of periodontitis.

KW - Porphyromonas gingivalis

KW - Periodontal stability

KW - Periodontitis progression

KW - Saliva

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