Salvage surgery for a super-responder by gefitinib therapy for advanced lung cancer

Kohei Hashimoto, Hirohisa Horinouchi, Takashi Ohtsuka, Mitsutomo Kohno, Yotaro Izumi, Yuichiro Hayashi, Hiroaki Nomori

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Salvage surgery after gefitinib therapy in a 66-year-old female with cT4N1M1a lung adenocarcinoma in the right middle lobe, which had gene mutation of epidermal growth factor receptor, is presented. The patient had bulky hilar lymph nodes, pleural dissemination, and pulmonary metastases in the ipsilateral lobes. After 3 courses of chemotherapy, the patient was treated with gefitinib, resulting in partial response, i.e. only the primary tumor and the middle lobe atelectasis remained. We performed the middle lobe lobectomy aimed at local control and pathological confirmation of the remaining tumor. Because the hilum of the middle lobe was occupied with scar tissue, its pulmonary vein had to be cut within the pericardium and its pulmonary artery and bronchus had to be transected simultaneously with a stapler. Pathological stage was yp-T2aN0N0 with Ef 2. For salvage surgery after good response to gefitinib therapy, it should be taken care to expose pulmonary vessels.

Original languageEnglish
Pages (from-to)851-854
Number of pages4
JournalGeneral Thoracic and Cardiovascular Surgery
Volume60
Issue number12
DOIs
Publication statusPublished - 2012 Dec

Fingerprint

Lung Neoplasms
erbB-1 Genes
Lung
Pulmonary Atelectasis
Pulmonary Veins
Pericardium
Bronchi
Pulmonary Artery
Cicatrix
Neoplasms
Therapeutics
Lymph Nodes
Neoplasm Metastasis
Drug Therapy
Mutation
gefitinib
Adenocarcinoma of lung

Keywords

  • Gefitinib
  • Lung cancer
  • Salvage surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Salvage surgery for a super-responder by gefitinib therapy for advanced lung cancer. / Hashimoto, Kohei; Horinouchi, Hirohisa; Ohtsuka, Takashi; Kohno, Mitsutomo; Izumi, Yotaro; Hayashi, Yuichiro; Nomori, Hiroaki.

In: General Thoracic and Cardiovascular Surgery, Vol. 60, No. 12, 12.2012, p. 851-854.

Research output: Contribution to journalArticle

Hashimoto, Kohei ; Horinouchi, Hirohisa ; Ohtsuka, Takashi ; Kohno, Mitsutomo ; Izumi, Yotaro ; Hayashi, Yuichiro ; Nomori, Hiroaki. / Salvage surgery for a super-responder by gefitinib therapy for advanced lung cancer. In: General Thoracic and Cardiovascular Surgery. 2012 ; Vol. 60, No. 12. pp. 851-854.
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