Saquayamycins, new aquayamycin-group antibiotics

Takeshi Uchida, Masaya Imoto, Yoshinori Watanabe, Keiko Miura, Toshiko Dobashi, Naoko Matsuda, Tsutomu Sawa, Hiroshi Naganawa, Masa Hamada, Tomio Takeuchi, Hamao Umezawa

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

From the culture broth of Streptomyces nodosus Mh190-16F3, four new antibiotics have been isolated, and named saquayamycins A, B, C and D. The compounds are glycosides of aquayamycin, and among aquayamycin-group antibiotics they are most closely related to P-1894B (vineomycin A1). All saquayamycins act on Gram-positive bacteria and inhibit the growth of adriamycin-sensitive and adriamycin-resistant P388 leukemia cells.

Original languageEnglish
Pages (from-to)1171-1181
Number of pages11
JournalThe Journal of Antibiotics
Volume38
Issue number9
DOIs
Publication statusPublished - 1985 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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  • Cite this

    Uchida, T., Imoto, M., Watanabe, Y., Miura, K., Dobashi, T., Matsuda, N., Sawa, T., Naganawa, H., Hamada, M., Takeuchi, T., & Umezawa, H. (1985). Saquayamycins, new aquayamycin-group antibiotics. The Journal of Antibiotics, 38(9), 1171-1181. https://doi.org/10.7164/antibiotics.38.1171