Saquayamycins, new aquayamycin-group antibiotics

T. Uchida, Masaya Imoto, Y. Watanabe, K. Miura, T. Dobashi, N. Matsuda, T. Sawa, H. Naganawa, M. Hamada, T. Takeuchi

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Abstract

From the culture broth of Streptomyces nodosus MH190-16F3, four new antibiotics have been isolated, and named saquayamycins A, B, C and D. The compounds are glycosides of aquayamycin, and among aquayamycin-group antibiotics they are most closely related to P-1894B (vineomycin A1). All saquayamycins act on Gram-positive bacteria and inhibit the growth of adriamycin-sensitive and adriamycin-resistant P388 leukemia cells.

Original languageEnglish
Pages (from-to)1171-1181
Number of pages11
JournalJournal of Antibiotics
Volume38
Issue number9
Publication statusPublished - 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Uchida, T., Imoto, M., Watanabe, Y., Miura, K., Dobashi, T., Matsuda, N., Sawa, T., Naganawa, H., Hamada, M., & Takeuchi, T. (1985). Saquayamycins, new aquayamycin-group antibiotics. Journal of Antibiotics, 38(9), 1171-1181.