Saquayamycins, new aquayamycin-group antibiotics

Takeshi Uchida, Masaya Imoto, Yoshinori Watanabe, Keiko Miura, Toshiko Dobashi, Naoko Matsuda, Tsutomu Sawa, Hiroshi Naganawa, Masa Hamada, Tomio Takeuchi, Hamao Umezawa

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

From the culture broth of Streptomyces nodosus Mh190-16F3, four new antibiotics have been isolated, and named saquayamycins A, B, C and D. The compounds are glycosides of aquayamycin, and among aquayamycin-group antibiotics they are most closely related to P-1894B (vineomycin A1). All saquayamycins act on Gram-positive bacteria and inhibit the growth of adriamycin-sensitive and adriamycin-resistant P388 leukemia cells.

Original languageEnglish
Pages (from-to)1171-1181
Number of pages11
JournalThe Journal of Antibiotics
Volume38
Issue number9
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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