SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation II. Structure elucidation

Tatsuro Kawamura, Etsu Tashiro, Kazutoshi Shindo, Masaya Imoto

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of Streptomyces sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties.

Original languageEnglish
Pages (from-to)312-317
Number of pages6
JournalJournal of Antibiotics
Volume61
Issue number5
DOIs
Publication statusPublished - 2008 May 1

Keywords

  • ER stress
  • Triene-ansamycin
  • XBP1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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