TY - JOUR
T1 - Scalable Fabrication of PEGDA Microneedles Using UV Exposure via a Rotating Prism
AU - Takahashi, H.
AU - Heo, Y. J.
AU - Shimoyama, I.
N1 - Funding Information:
Manuscript received June 10, 2017; revised July 27, 2017; accepted August 11, 2017. Date of publication August 29, 2017; date of current version September 29, 2017. This work was supported by the National Research Foundation of Korea under Grant NRF-2016K2A9A2A08003732. Subject Editor C. Ahn. (H. Takahashi and Y. J. Heo contributed equally to this work.) (Corresponding authors: Y. J. Heo; I. Shimoyama.) H. Takahashi is with the Department of Mechano-Informatics, Graduate School of Information Science and Technology, University of Tokyo, Tokyo 113-8656, Japan (e-mail: takahashi@leopard.t.u-tokyo.ac.jp).
Publisher Copyright:
© 1992-2012 IEEE.
PY - 2017/10
Y1 - 2017/10
N2 - We propose a simple, fast, height-scalable, and direct way to fabricate highly biocompatible polyethylene glycol diacrylate (PEGDA) microneedles. A needle-shaped distribution of ultraviolet (UV) exposure dose is formed in PEGDA by applying UV light through a rotating prism. A prism makes UV light rays bend, such that the base angle of the prism determines the inclined angle of the light. Thus, the microneedle height can be controlled by varying the base angles of the prism. We experimentally demonstrate the direct height-scalable potential. The microneedle height decreases and the microneedle tip angle increases with increases in the base angle of the prism. These results indicate that the microneedle geometry can be easily controlled by the base angle of a prism without additional microfabrication. In addition, unlike photoresist microneedles, PEGDA does not require any thermal baking, thus enabling well-defined symmetric needle formation with short process time. Therefore, the present method can facilitate PEGDA microneedles to practical applications.
AB - We propose a simple, fast, height-scalable, and direct way to fabricate highly biocompatible polyethylene glycol diacrylate (PEGDA) microneedles. A needle-shaped distribution of ultraviolet (UV) exposure dose is formed in PEGDA by applying UV light through a rotating prism. A prism makes UV light rays bend, such that the base angle of the prism determines the inclined angle of the light. Thus, the microneedle height can be controlled by varying the base angles of the prism. We experimentally demonstrate the direct height-scalable potential. The microneedle height decreases and the microneedle tip angle increases with increases in the base angle of the prism. These results indicate that the microneedle geometry can be easily controlled by the base angle of a prism without additional microfabrication. In addition, unlike photoresist microneedles, PEGDA does not require any thermal baking, thus enabling well-defined symmetric needle formation with short process time. Therefore, the present method can facilitate PEGDA microneedles to practical applications.
KW - Polyethylene glycol diacrylate (PEGDA) microneedles
KW - inclined/rotated ultraviolet (UV) exposure
KW - rotating prism
KW - transdermal drug delivery system
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U2 - 10.1109/JMEMS.2017.2740177
DO - 10.1109/JMEMS.2017.2740177
M3 - Article
AN - SCOPUS:85028709094
SN - 1057-7157
VL - 26
SP - 990
EP - 992
JO - Journal of Microelectromechanical Systems
JF - Journal of Microelectromechanical Systems
IS - 5
M1 - 8022864
ER -