Scalable Fabrication of PEGDA Microneedles Using UV Exposure via a Rotating Prism

Hidetoshi Takahashi, Y. J. Heo, I. Shimoyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We propose a simple, fast, height-scalable, and direct way to fabricate highly biocompatible polyethylene glycol diacrylate (PEGDA) microneedles. A needle-shaped distribution of ultraviolet (UV) exposure dose is formed in PEGDA by applying UV light through a rotating prism. A prism makes UV light rays bend, such that the base angle of the prism determines the inclined angle of the light. Thus, the microneedle height can be controlled by varying the base angles of the prism. We experimentally demonstrate the direct height-scalable potential. The microneedle height decreases and the microneedle tip angle increases with increases in the base angle of the prism. These results indicate that the microneedle geometry can be easily controlled by the base angle of a prism without additional microfabrication. In addition, unlike photoresist microneedles, PEGDA does not require any thermal baking, thus enabling well-defined symmetric needle formation with short process time. Therefore, the present method can facilitate PEGDA microneedles to practical applications.

Original languageEnglish
Article number8022864
Pages (from-to)990-992
Number of pages3
JournalJournal of Microelectromechanical Systems
Volume26
Issue number5
DOIs
Publication statusPublished - 2017 Oct 1
Externally publishedYes

Keywords

  • inclined/rotated ultraviolet (UV) exposure
  • Polyethylene glycol diacrylate (PEGDA) microneedles
  • rotating prism
  • transdermal drug delivery system

ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering

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