TY - JOUR
T1 - Scalable representation of time in the hippocampus
AU - Shimbo, Akihiro
AU - Izawa, Ei Ichi
AU - Fujisawa, Shigeyoshi
N1 - Funding Information:
This study was supported by the JSPS KAKENHI grants (15H05876, 16H01519, 18H02711, and 18H05525 for S.F.; 20K16480 for A.S.), the Mitsubishi Foundation (S.F.), the RIKEN JRA fellowship (A.S.), and the Keio University Doctorate Student Grant-in-Aid Program (A.S.).
Publisher Copyright:
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
PY - 2021/2/3
Y1 - 2021/2/3
N2 - Hippocampal “time cells” encode specific moments of temporally organized experiences that may support hippocampal functions for episodic memory. However, little is known about the reorganization of the temporal representation of time cells during changes in temporal structures of episodes. We investigated CA1 neuronal activity during temporal bisection tasks, in which the sets of time intervals to be discriminated were designed to be extended or contracted across the blocks of trials. Assemblies of neurons encoded elapsed time during the interval, and the representation was scaled when the set of interval times was varied. Theta phase precession and theta sequences of time cells were also scalable, and the fine temporal relationships were preserved between pairs in theta cycles. Moreover, theta sequences reflected the rats' decisions on the basis of their time estimation. These findings demonstrate that scalable features of time cells may support the capability of flexible temporal representation for memory formation.
AB - Hippocampal “time cells” encode specific moments of temporally organized experiences that may support hippocampal functions for episodic memory. However, little is known about the reorganization of the temporal representation of time cells during changes in temporal structures of episodes. We investigated CA1 neuronal activity during temporal bisection tasks, in which the sets of time intervals to be discriminated were designed to be extended or contracted across the blocks of trials. Assemblies of neurons encoded elapsed time during the interval, and the representation was scaled when the set of interval times was varied. Theta phase precession and theta sequences of time cells were also scalable, and the fine temporal relationships were preserved between pairs in theta cycles. Moreover, theta sequences reflected the rats' decisions on the basis of their time estimation. These findings demonstrate that scalable features of time cells may support the capability of flexible temporal representation for memory formation.
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U2 - 10.1126/sciadv.abd7013
DO - 10.1126/sciadv.abd7013
M3 - Article
C2 - 33536211
AN - SCOPUS:85101030290
SN - 2375-2548
VL - 7
JO - Science advances
JF - Science advances
IS - 6
M1 - eabd7013
ER -